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Target
Protein kinase C delta type
Ligand
BDBM3239
Substrate
n/a
Meas. Tech.
ChEBML_160645
IC50
20±n/a nM
Citation
 Heerding, JM; Lampe, JW; Darges, JW; Stamper, ML Protein kinase C inhibitory activities of balanol analogs bearing carboxylic acid replacements Bioorg Med Chem Lett 5:1839-1842 (1995)    Article
Target
Name:
Protein kinase C delta type
Synonyms:
KPCD_HUMAN | PKC delta | PKCD | PRKCD | Protein Kinase C- delta | Protein kinase C, PKC; classical/novel | nPKC-delta
Type:
Enzyme
Mol. Mass.:
77516.79
Organism:
Homo sapiens (Human)
Description:
The recombinant human PKC enzymes were produced using a baculovirus expression system in SF9 cells
Residue:
676
Sequence:
MAPFLRIAFNSYELGSLQAEDEANQPFCAVKMKEALSTERGKTLVQKKPTMYPEWKSTFDAHIYEGRVIQIVLMRAAEEPVSEVTVGVSVLAERCKKNNGKAEFWLDLQPQAKVLMSVQYFLEDVDCKQSMRSEDEAKFPTMNRRGAIKQAKIHYIKNHEFIATFFGQPTFCSVCKDFVWGLNKQGYKCRQCNAAIHKKCIDKIIGRCTGTAANSRDTIFQKERFNIDMPHRFKVHNYMSPTFCDHCGSLLWGLVKQGLKCEDCGMNVHHKCREKVANLCGINQKLLAEALNQVTQRASRRSDSASSEPVGIYQGFEKKTGVAGEDMQDNSGTYGKIWEGSSKCNINNFIFHKVLGKGSFGKVLLGELKGRGEYFAIKALKKDVVLIDDDVECTMVEKRVLTLAAENPFLTHLICTFQTKDHLFFVMEFLNGGDLMYHIQDKGRFELYRATFYAAEIMCGLQFLHSKGIIYRDLKLDNVLLDRDGHIKIADFGMCKENIFGESRASTFCGTPDYIAPEILQGLKYTFSVDWWSFGVLLYEMLIGQSPFHGDDEDELFESIRVDTPHYPRWITKESKDILEKLFEREPTKRLGVTGNIKIHPFFKTINWTLLEKRRLEPPFRPKVKSPRDYSNFDQEFLNEKARLSYSDKNLIDSMDQSAFAGFSFVNPKFEHLLED
  
Inhibitor
Name:
BDBM3239
Synonyms:
(1R,2R)-2-[(4-hydroxybenzene)amido]cyclopentyl 3,5-dihydroxy-4-{[2-hydroxy-6-(1H-1,2,3,4-tetrazol-5-yl)phenyl]carbonyl}benzoate | Modified Benzophenone Carboxylic Acid, Balanol Analog 39 | trans-2-[4-(6-Hydroxy-2-tetrazolylbenzoyl)-3,5-dihydroxybenzoyloxy]-1-(4-hydroxybenzamido)cyclopentane
Type:
Small organic molecule
Emp. Form.:
C27H23N5O8
Mol. Mass.:
545.5002
SMILES:
Oc1ccc(cc1)C(=O)N[C@@H]1CCC[C@H]1OC(=O)c1cc(O)c(C(=O)c2c(O)cccc2-c2nnn[nH]2)c(O)c1 |r|
Structure:
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