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Target
Type-2 angiotensin II receptor
Ligand
BDBM50285349
Substrate
n/a
Meas. Tech.
ChEBML_35281
IC50
22±n/a nM
Citation
 Fitch, KJ; Walsh, TF; Patchett, AA; Chang, RS; Siegl, PK; Faust, KA; Chen, TB; Lotti, VJ; Kivlighn, SD; Zingaro, GJ; Greenlee, WJ AT1 selective angiotensin II antagonists with phenoxyphenylacetic acid as a biphenyl replacement part I Bioorg Med Chem Lett 5:155-158 (1995)    Article
Target
Name:
Type-2 angiotensin II receptor
Synonyms:
AGTR2 | AGTR2_HUMAN | AT2 | Angiotensin II receptor | Angiotensin II type 2 (AT-2) receptor | Angiotensin II, central | Type-2 angiotensin II receptor
Type:
Enzyme Catalytic Domain
Mol. Mass.:
41201.61
Organism:
Homo sapiens (Human)
Description:
Angiotensin II, central 0 0::P50052
Residue:
363
Sequence:
MKGNSTLATTSKNITSGLHFGLVNISGNNESTLNCSQKPSDKHLDAIPILYYIIFVIGFLVNIVVVTLFCCQKGPKKVSSIYIFNLAVADLLLLATLPLWATYYSYRYDWLFGPVMCKVFGSFLTLNMFASIFFITCMSVDRYQSVIYPFLSQRRNPWQASYIVPLVWCMACLSSLPTFYFRDVRTIEYLGVNACIMAFPPEKYAQWSAGIALMKNILGFIIPLIFIATCYFGIRKHLLKTNSYGKNRITRDQVLKMAAAVVLAFIICWLPFHVLTFLDALAWMGVINSCEVIAVIDLALPFAILLGFTNSCVNPFLYCFVGNRFQQKLRSVFRVPITWLQGKRESMSCRKSSSLREMETFVS
  
Inhibitor
Name:
BDBM50285349
Synonyms:
(2-Chloro-phenyl)-[4-(7-methyl-2-propyl-imidazo[4,5-b]pyridin-3-ylmethyl)-phenoxy]-acetic acid | CHEMBL40381
Type:
Small organic molecule
Emp. Form.:
C25H24ClN3O3
Mol. Mass.:
449.929
SMILES:
CCCc1nc2c(C)ccnc2n1Cc1ccc(OC(C(O)=O)c2ccccc2Cl)cc1
Structure:
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