Reaction Details  Report a problem with these data
Target
Prostaglandin E2 receptor EP2 subtype
Ligand
BDBM50293498
Substrate
n/a
Meas. Tech.
ChEMBL_570545 (CHEMBL1027714)
EC50
44±n/a nM
Citation
 Cameron, KO; Lefker, BA; Ke, HZ; Li, M; Zawistoski, MP; Tjoa, CM; Wright, AS; DeNinno, SL; Paralkar, VM; Owen, TA; Yu, L; Thompson, DD Discovery of CP-533536: an EP2 receptor selective prostaglandin E2 (PGE2) agonist that induces local bone formation. Bioorg Med Chem Lett 19:2075-8 (2009) [PubMed]  Article
Target
Name:
Prostaglandin E2 receptor EP2 subtype
Synonyms:
PE2R2_RAT | Prostanoid EP2 receptor | Ptger2
Type:
PROTEIN
Mol. Mass.:
39786.37
Organism:
Rattus norvegicus
Description:
ChEMBL_1501400
Residue:
357
Sequence:
MDNSFNDSRRVENCESRQYLLSDESPAISSVMFTAGVLGNLIALALLARRWRGDTGCSAGSRTSISLFHVLVTELVLTDLLGTCLISPVVLASYSRNQTLVALAPESRACTYFAFTMTFFSLATMLMLFAMALERYLAIGHPYFYRRRVSRRGGLAVLPAIYGVSLLFCSLPLLNYGEYVQYCPGTWCFIQHGRTAYLQLYATVLLLLIVAVLGCNISVILNLIRMQLRSKRSRCGLSGSSLRGPGSRRRGERTSMAEETDHLILLAIMTITFAVCSLPFTIFAYMDETSSRKEKWDLRALRFLSVNSIIDPWVFVILRPPVLRLMRSVLCCRTSLRAPEAPGASCSTQQTDLCGQL
  
Inhibitor
Name:
BDBM50293498
Synonyms:
7-(N-(4-(1-hydroxyhexyl)benzyl)methylsulfonamido)heptanoic acid | CHEMBL562411
Type:
Small organic molecule
Emp. Form.:
C21H35NO5S
Mol. Mass.:
413.571
SMILES:
CCCCCC(O)c1ccc(CN(CCCCCCC(O)=O)S(C)(=O)=O)cc1
Structure:
Search PDB for entries with ligand similarity: