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Target
Neuromedin-B receptor
Ligand
BDBM50295227
Substrate
n/a
Meas. Tech.
ChEMBL_577514 (CHEMBL1057866)
IC50
2000±n/a nM
Citation
 Fu, J; Shuttleworth, SJ; Connors, RV; Chai, A; Coward, P Discovery and optimization of a novel Neuromedin B receptor antagonist. Bioorg Med Chem Lett 19:4264-7 (2009) [PubMed]  Article
Target
Name:
Neuromedin-B receptor
Synonyms:
Bombesin 1 | NMB-R | NMBR | NMBR_HUMAN | Neuromedin B | Neuromedin B receptor | Neuromedin-B receptor | Neuromedin-B-preferring bombesin receptor
Type:
Enzyme Catalytic Domain
Mol. Mass.:
43447.11
Organism:
Homo sapiens (Human)
Description:
Bombesin 1 NMBR 0::P28336
Residue:
390
Sequence:
MPSKSLSNLSVTTGANESGSVPEGWERDFLPASDGTTTELVIRCVIPSLYLLIITVGLLGNIMLVKIFITNSAMRSVPNIFISNLAAGDLLLLLTCVPVDASRYFFDEWMFGKVGCKLIPVIQLTSVGVSVFTLTALSADRYRAIVNPMDMQTSGALLRTCVKAMGIWVVSVLLAVPEAVFSEVARISSLDNSSFTACIPYPQTDELHPKIHSVLIFLVYFLIPLAIISIYYYHIAKTLIKSAHNLPGEYNEHTKKQMETRKRLAKIVLVFVGCFIFCWFPNHILYMYRSFNYNEIDPSLGHMIVTLVARVLSFGNSCVNPFALYLLSESFRRHFNSQLCCGRKSYQERGTSYLLSSSAVRMTSLKSNAKNMVTNSVLLNGHSMKQEMAL
  
Inhibitor
Name:
BDBM50295227
Synonyms:
11-(2-chloro-6-fluorophenyl)-3-(4-methoxyphenyl)-8-methyl-2,3,4,5,10,11-hexahydro-1H-dibenzo[b,e][1,4]diazepin-1-one | CHEMBL552257
Type:
Small organic molecule
Emp. Form.:
C27H24ClFN2O2
Mol. Mass.:
462.943
SMILES:
COc1ccc(cc1)C1CC(=O)C2C(Nc3cc(C)ccc3N=C2C1)c1c(F)cccc1Cl |c:24|
Structure:
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