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Target
Enoyl-acyl-carrier protein reductase
Ligand
BDBM25416
Substrate
n/a
Meas. Tech.
ChEMBL_577751 (CHEMBL1053058)
IC50
230±n/a nM
Citation
 Frecer, V; Megnassan, E; Miertus, S Design and in silico screening of combinatorial library of antimalarial analogs of triclosan inhibiting Plasmodium falciparum enoyl-acyl carrier protein reductase. Eur J Med Chem 44:3009-19 (2009) [PubMed]  Article
Target
Name:
Enoyl-acyl-carrier protein reductase
Synonyms:
n/a
Type:
PROTEIN
Mol. Mass.:
49770.86
Organism:
Plasmodium falciparum
Description:
ChEMBL_795989
Residue:
432
Sequence:
MNKISQRLLFLFLHFYTTVCFIQNNTQKTFHNVLQNEQIRGKEKAFYRKEKRENIFIGNKMKHVHNMNNTHNNNHYMEKEEQDASNINKIKEENKNEDICFIAGIGDTNGYGWGIAKELSKRNVKIIFGIWPPVYNIFMKNYKNGKFDNDMIIDKDKKMNILDMLPFDASFDTANDIDEETKNNKRYNMLQNYPIEDVANLIHQKYGKINMLVHSLANAKEVQKDLLNTSRKGYLDALSKSSYSLISLCKYFVNIMKPQSSIISLTYHASQKVVPGYGGGMSSAKAALESDTRVLAYHLGRNYNIRINTISAGPLKSRAATAINKLNNTYENNTNQNKNRNSHDVHNIMNNSGEKEEKKNSASQNYTFIDYAIEYSEKYAPLRQKLLSTDIGSVASFLLSRESRAITGQTIYVDNGLNIMFLPDDIYRNENE
  
Inhibitor
Name:
BDBM25416
Synonyms:
2-(2,4-dichlorophenoxy)-5-(3-methylphenyl)phenol | Triclosan derivative, 17
Type:
Small organic molecule
Emp. Form.:
C19H14Cl2O2
Mol. Mass.:
345.219
SMILES:
Cc1cccc(c1)-c1ccc(Oc2ccc(Cl)cc2Cl)c(O)c1
Structure:
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