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Target
Enoyl-acyl-carrier protein reductase
Ligand
BDBM25422
Substrate
n/a
Meas. Tech.
ChEMBL_577751 (CHEMBL1053058)
IC50
700±n/a nM
Citation
 Frecer, V; Megnassan, E; Miertus, S Design and in silico screening of combinatorial library of antimalarial analogs of triclosan inhibiting Plasmodium falciparum enoyl-acyl carrier protein reductase. Eur J Med Chem 44:3009-19 (2009) [PubMed]  Article
Target
Name:
Enoyl-acyl-carrier protein reductase
Synonyms:
n/a
Type:
PROTEIN
Mol. Mass.:
49770.86
Organism:
Plasmodium falciparum
Description:
ChEMBL_795989
Residue:
432
Sequence:
MNKISQRLLFLFLHFYTTVCFIQNNTQKTFHNVLQNEQIRGKEKAFYRKEKRENIFIGNKMKHVHNMNNTHNNNHYMEKEEQDASNINKIKEENKNEDICFIAGIGDTNGYGWGIAKELSKRNVKIIFGIWPPVYNIFMKNYKNGKFDNDMIIDKDKKMNILDMLPFDASFDTANDIDEETKNNKRYNMLQNYPIEDVANLIHQKYGKINMLVHSLANAKEVQKDLLNTSRKGYLDALSKSSYSLISLCKYFVNIMKPQSSIISLTYHASQKVVPGYGGGMSSAKAALESDTRVLAYHLGRNYNIRINTISAGPLKSRAATAINKLNNTYENNTNQNKNRNSHDVHNIMNNSGEKEEKKNSASQNYTFIDYAIEYSEKYAPLRQKLLSTDIGSVASFLLSRESRAITGQTIYVDNGLNIMFLPDDIYRNENE
  
Inhibitor
Name:
BDBM25422
Synonyms:
3-chloro-4-[2-hydroxy-4-(pyridin-2-yl)phenoxy]benzonitrile | Triclosan derivative, 23
Type:
Small organic molecule
Emp. Form.:
C18H11ClN2O2
Mol. Mass.:
322.745
SMILES:
Oc1cc(ccc1Oc1ccc(cc1Cl)C#N)-c1ccccn1
Structure:
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