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Target
Glutaminyl-peptide cyclotransferase
Ligand
BDBM50299858
Substrate
n/a
Meas. Tech.
ChEMBL_589681 (CHEMBL1057686)
Ki
2.6±n/a nM
Citation
 Buchholz, M; Hamann, A; Aust, S; Brandt, W; Böhme, L; Hoffmann, T; Schilling, S; Demuth, HU; Heiser, U Inhibitors for human glutaminyl cyclase by structure based design and bioisosteric replacement. J Med Chem 52:7069-80 (2009) [PubMed]  Article
Target
Name:
Glutaminyl-peptide cyclotransferase
Synonyms:
Glutaminyl Cyclase | Glutaminyl cyclase (QC) | Glutaminyl-peptide cyclotransferase | Glutaminyl-peptide cyclotransferase precursor (QC) | Glutaminyl-tRNA cyclotransferase | Glutamyl cyclase (QC) | QPCT | QPCT_HUMAN
Type:
Enzyme
Mol. Mass.:
40877.05
Organism:
Homo sapiens (Human)
Description:
Q16769
Residue:
361
Sequence:
MAGGRHRRVVGTLHLLLLVAALPWASRGVSPSASAWPEEKNYHQPAILNSSALRQIAEGTSISEMWQNDLQPLLIERYPGSPGSYAARQHIMQRIQRLQADWVLEIDTFLSQTPYGYRSFSNIISTLNPTAKRHLVLACHYDSKYFSHWNNRVFVGATDSAVPCAMMLELARALDKKLLSLKTVSDSKPDLSLQLIFFDGEEAFLHWSPQDSLYGSRHLAAKMASTPHPPGARGTSQLHGMDLLVLLDLIGAPNPTFPNFFPNSARWFERLQAIEHELHELGLLKDHSLEGRYFQNYSYGGVIQDDHIPFLRRGVPVLHLIPSPFPEVWHTMDDNEENLDESTIDNLNKILQVFVLEYLHL
  
Inhibitor
Name:
BDBM50299858
Synonyms:
1-(3,4-Dimethoxyphenyl)-N-(3-(5-methyl-1H-imidazol-1-yl)propyl)cyclopropanecarbothioamide | CHEMBL583368
Type:
Small organic molecule
Emp. Form.:
C19H25N3O2S
Mol. Mass.:
359.486
SMILES:
COc1ccc(cc1OC)C1(CC1)C(=S)NCCCn1cncc1C
Structure:
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