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Target
Mitogen-activated protein kinase 9
Ligand
BDBM50206421
Substrate
n/a
Meas. Tech.
ChEMBL_599888 (CHEMBL1045453)
IC50
1280±n/a nM
Citation
 Peifer, C; Abadleh, M; Bischof, J; Hauser, D; Schattel, V; Hirner, H; Knippschild, U; Laufer, S 3,4-Diaryl-isoxazoles and -imidazoles as potent dual inhibitors of p38alpha mitogen activated protein kinase and casein kinase 1delta. J Med Chem 52:7618-30 (2009) [PubMed]  Article
Target
Name:
Mitogen-activated protein kinase 9
Synonyms:
JNK-55 | JNK2 | JNK2/JNK3 | MAPK9 | MK09_HUMAN | Mitogen-Activated Protein Kinase 9 (JNK2) | Mitogen-activated protein kinase 8/9 | PRKM9 | SAPK1A | Stress-activated protein kinase JNK2 | c-Jun N-terminal kinase 2 | c-Jun N-terminal kinase 2 (JNK2)
Type:
Enzyme
Mol. Mass.:
48131.49
Organism:
Homo sapiens (Human)
Description:
JNK-2 was purchased from Upstate Cell Signaling Solutions (formerly Upstate Biotechnology).
Residue:
424
Sequence:
MSDSKCDSQFYSVQVADSTFTVLKRYQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSRPFQNQTHAKRAYRELVLLKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIHMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTACTNFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGELVKGCVIFQGTDHIDQWNKVIEQLGTPSAEFMKKLQPTVRNYVENRPKYPGIKFEELFPDWIFPSESERDKIKTSQARDLLSKMLVIDPDKRISVDEALRHPYITVWYDPAEAEAPPPQIYDAQLEEREHAIEEWKELIYKEVMDWEERSKNGVVKDQPSDAAVSSNATPSQSSSINDISSMSTEQTLASDTDSSLDASTGPLEGCR
  
Inhibitor
Name:
BDBM50206421
Synonyms:
3-(4-fluorophenyl)-5-isopropyl-4-(pyridin-4-yl)isoxazole | 4-(3-(4-fluorophenyl)-5-isopropylisoxazol-4-yl)pyridine | 4-[3-(4-fluorophenyl)-5-isopropylisoxazol-4-yl]pyridine | CHEMBL220227
Type:
Small organic molecule
Emp. Form.:
C17H15FN2O
Mol. Mass.:
282.3122
SMILES:
CC(C)c1onc(c1-c1ccncc1)-c1ccc(F)cc1
Structure:
Search PDB for entries with ligand similarity: