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Target
Prostaglandin E2 receptor EP1 subtype
Ligand
BDBM50307405
Substrate
n/a
Meas. Tech.
ChEMBL_610984 (CHEMBL1070315)
Ki
>10000±n/a nM
Citation
 Asada, M; Iwahashi, M; Obitsu, T; Kinoshita, A; Nakai, Y; Onoda, T; Nagase, T; Tanaka, M; Yamaura, Y; Takizawa, H; Yoshikawa, K; Sato, K; Narita, M; Ohuchida, S; Nakai, H; Toda, M 3-(2-Aminocarbonylphenyl)propanoic acid analogs as potent and selective EP3 receptor antagonists. part 2: optimization of the side chains to improve in vitro and in vivo potencies. Bioorg Med Chem 18:1641-58 (2010) [PubMed]  Article
Target
Name:
Prostaglandin E2 receptor EP1 subtype
Synonyms:
PE2R1_MOUSE | PGE receptor, EP1 subtype | Prostaglandin E1 | Prostaglandin E2 receptor EP1 subtype | Prostanoid EP1 receptor | Ptger1 | Ptgerep1
Type:
G-protein coupled receptor
Mol. Mass.:
43000.62
Organism:
Mus musculus (Mouse)
Description:
n/a
Residue:
405
Sequence:
MSPCGLNLSLADEAATCATPRLPNTSVVLPTGDNGTSPALPIFSMTLGAVSNVLALALLAQVAGRMRRRRSAATFLLFVASLLAIDLAGHVIPGALVLRLYTAGRAPAGGACHFLGGCMVFFGLCPLLLGCGMAVERCVGVTQPLIHAARVSVARARLALAVLAAMALAVALLPLVHVGRYELQYPGTWCFISLGPRGGWRQALLAGLFAGLGLAALLAALVCNTLSGLALLRARWRRRRSRRFRKTAGPDDRRRWGSRGPRLASASSASSITSATATLRSSRGGGSARRVHAHDVEMVGQLVGIMVVSCICWSPLLVLVVLAIGGWNSNSLQRPLFLAVRLASWNQILDPWVYILLRQAMLRQLLRLLPLRVSAKGGPTELGLTKSAWEASSLRSSRHSGFSHL
  
Inhibitor
Name:
BDBM50307405
Synonyms:
3-{2-({[1-(3,5-Dimethylphenyl)-3-methylbutyl]amino}-carbonyl)-4-[(3-fluorophenoxy)methyl]phenyl}propanoic acid | CHEMBL597146
Type:
Small organic molecule
Emp. Form.:
C30H34FNO4
Mol. Mass.:
491.5937
SMILES:
CC(C)CC(NC(=O)c1cc(COc2cccc(F)c2)ccc1CCC(O)=O)c1cc(C)cc(C)c1
Structure:
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