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Target
Motilin receptor
Ligand
BDBM50311425
Substrate
n/a
Meas. Tech.
ChEMBL_622559 (CHEMBL1117503)
EC50
12.59±n/a nM
Citation
 Bailey, JM; Scott, JS; Basilla, JB; Bolton, VJ; Boyfield, I; Evans, DG; Fleury, E; Heightman, TD; Jarvie, EM; Lawless, K; Matthews, KL; McKay, F; Mok, H; Muir, A; Orlek, BS; Sanger, GJ; Stemp, G; Stevens, AJ; Thompson, M; Ward, J; Vaidya, K; Westaway, SM The discovery and optimisation of benzazepine sulfonamide and sulfones as potent agonists of the motilin receptor. Bioorg Med Chem Lett 19:6452-8 (2009) [PubMed]  Article
Target
Name:
Motilin receptor
Synonyms:
G-protein coupled receptor 38 | GPR38 | MLNR | MTLR | MTLR1 | MTLR_HUMAN
Type:
PROTEIN
Mol. Mass.:
45365.95
Organism:
Homo sapiens (Human)
Description:
ChEMBL_122664
Residue:
412
Sequence:
MGSPWNGSDGPEGAREPPWPALPPCDERRCSPFPLGALVPVTAVCLCLFVVGVSGNVVTVMLIGRYRDMRTTTNLYLGSMAVSDLLILLGLPFDLYRLWRSRPWVFGPLLCRLSLYVGEGCTYATLLHMTALSVERYLAICRPLRARVLVTRRRVRALIAVLWAVALLSAGPFLFLVGVEQDPGISVVPGLNGTARIASSPLASSPPLWLSRAPPPSPPSGPETAEAAALFSRECRPSPAQLGALRVMLWVTTAYFFLPFLCLSILYGLIGRELWSSRRPLRGPAASGRERGHRQTVRVLLVVVLAFIICWLPFHVGRIIYINTEDSRMMYFSQYFNIVALQLFYLSASINPILYNLISKKYRAAAFKLLLARKSRPRGFHRSRDTAGEVAGDTGGDTVGYTETSANVKTMG
  
Inhibitor
Name:
BDBM50311425
Synonyms:
7-((4'-fluorobiphenyl-4-ylsulfonyl)methyl)-2,3,4,5-tetrahydro-1H-benzo[d]azepine | CHEMBL1078345
Type:
Small organic molecule
Emp. Form.:
C23H22FNO2S
Mol. Mass.:
395.49
SMILES:
Fc1ccc(cc1)-c1ccc(cc1)S(=O)(=O)Cc1ccc2CCNCCc2c1
Structure:
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