Reaction Details  Report a problem with these data
Target
5-hydroxytryptamine receptor 2C
Ligand
BDBM50314620
Substrate
n/a
Meas. Tech.
ChEMBL_625151 (CHEMBL1115172)
Ki
324±n/a nM
Citation
 Liu, KK; Lefker, BA; Dombroski, MA; Chiang, P; Cornelius, P; Patterson, TA; Zeng, Y; Santucci, S; Tomlinson, E; Gibbons, CP; Marala, R; Brown, JA; Kong, JX; Lee, E; Werner, W; Wenzel, Z; Giragossian, C; Chen, H; Coffey, SB Orally active and brain permeable proline amides as highly selective 5HT2c agonists for the treatment of obesity. Bioorg Med Chem Lett 20:2365-9 (2010) [PubMed]  Article
Target
Name:
5-hydroxytryptamine receptor 2C
Synonyms:
5-HT-1C | 5-HT-2C | 5-HT1C | 5-HT2C | 5-HT2C-INI | 5-HT2c VGI | 5-HTR2C | 5-hydroxytryptamine receptor 1C | 5-hydroxytryptamine receptor 2C (5-HT-2C) | 5-hydroxytryptamine receptor 2C (5HT-2C) | 5HT-1C | 5HT2C_HUMAN | HTR1C | HTR2C | Serotonin (5-HT3) receptor | Serotonin 2c (5-HT2c) receptor | Serotonin Receptor 2C
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
51836.79
Organism:
Homo sapiens (Human)
Description:
P28335
Residue:
458
Sequence:
MVNLRNAVHSFLVHLIGLLVWQSDISVSPVAAIVTDIFNTSDGGRFKFPDGVQNWPALSIVIIIIMTIGGNILVIMAVSMEKKLHNATNYFLMSLAIADMLVGLLVMPLSLLAILYDYVWPLPRYLCPVWISLDVLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAIMKIAIVWAISIGVSVPIPVIGLRDEEKVFVNNTTCVLNDPNFVLIGSFVAFFIPLTIMVITYCLTIYVLRRQALMLLHGHTEEPPGLSLDFLKCCKRNTAEEENSANPNQDQNARRRKKKERRPRGTMQAINNERKASKVLGIVFFVFLIMWCPFFITNILSVLCEKSCNQKLMEKLLNVFVWIGYVCSGINPLVYTLFNKIYRRAFSNYLRCNYKVEKKPPVRQIPRVAATALSGRELNVNIYRHTNEPVIEKASDNEPGIEMQVENLELPVNPSSVVSERISSV
  
Inhibitor
Name:
BDBM50314620
Synonyms:
(S)-N-(4-(trifluoromethoxy)benzyl)pyrrolidine-2-carboxamide | CHEMBL1090399
Type:
Small organic molecule
Emp. Form.:
C13H15F3N2O2
Mol. Mass.:
288.2656
SMILES:
FC(F)(F)Oc1ccc(CNC(=O)[C@@H]2CCCN2)cc1 |r|
Structure:
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