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Target
Induced myeloid leukemia cell differentiation protein Mcl-1
Ligand
BDBM50316815
Substrate
n/a
Meas. Tech.
ChEMBL_629095 (CHEMBL1121053)
IC50
12500±n/a nM
Citation
 Oh, H; Jensen, PR; Murphy, BT; Fiorilla, C; Sullivan, JF; Ramsey, T; Fenical, W Cryptosphaerolide, a cytotoxic Mcl-1 inhibitor from a marine-derived ascomycete related to the genus Cryptosphaeria. J Nat Prod 73:998-1001 (2010) [PubMed]  Article
Target
Name:
Induced myeloid leukemia cell differentiation protein Mcl-1
Synonyms:
BCL2L3 | Bcl-2-like protein 3 | Bcl-2-like protein 3 (Mcl-1) | Bcl-2-related protein EAT/mcl1 | Bcl2-L-3 | Induced myeloid leukemia cell differentiation protein (Mcl-1) | MCL1 | MCL1_HUMAN | Mcl-1 | Myeloid Cell factor-1 (Mcl-1) | Myeloid cell leukemia sequence 1 (BCL2-related) | mcl1/EAT
Type:
Membrane; Single-pass membrane protein
Mol. Mass.:
37332.87
Organism:
Homo sapiens (Human)
Description:
Q07820
Residue:
350
Sequence:
MFGLKRNAVIGLNLYCGGAGLGAGSGGATRPGGRLLATEKEASARREIGGGEAGAVIGGSAGASPPSTLTPDSRRVARPPPIGAEVPDVTATPARLLFFAPTRRAAPLEEMEAPAADAIMSPEEELDGYEPEPLGKRPAVLPLLELVGESGNNTSTDGSLPSTPPPAEEEEDELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHVEDLEGGIRNVLLAFAGVAGVGAGLAYLIR
  
Inhibitor
Name:
BDBM50316815
Synonyms:
(1R,3S,4R,8S,10R,11S,14R)-4-methoxy-10,11-dimethyl-7-methylidene-2,5-dioxatetracyclo[8.4.0.0^{1,3}.0^{4,8}]tetradecan-14-yl 2-hydroxy-2-(hydroxymethyl)-4,6-dimethyloctanoate | CHEMBL1097105
Type:
Small organic molecule
Emp. Form.:
C27H44O7
Mol. Mass.:
480.6341
SMILES:
CCC(C)CC(C)CC(O)(CO)C(=O)O[C@@H]1CC[C@H](C)[C@@]2(C)C[C@H]3C(=C)CO[C@@]3(OC)[C@H]3O[C@@]123 |r|
Structure:
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