Reaction Details  Report a problem with these data
Target
Carbonic anhydrase 2
Ligand
BDBM50321257
Substrate
n/a
Meas. Tech.
ChEMBL_638634 (CHEMBL1168165)
Ki
14600±n/a nM
Citation
 Alp, C; Ekinci, D; Gültekin, MS; Sentürk, M; Sahin, E; Küfrevioglu, OI A novel and one-pot synthesis of new 1-tosyl pyrrol-2-one derivatives and analysis of carbonic anhydrase inhibitory potencies. Bioorg Med Chem 18:4468-74 (2010) [PubMed]  Article
Target
Name:
Carbonic anhydrase 2
Synonyms:
CA-II | CA2 | CAC | CAH2_HUMAN | Carbonate dehydratase II | Carbonic anhydrase 2 (CA II) | Carbonic anhydrase 2 (CA-II) | Carbonic anhydrase 2 (Recombinant CA II) | Carbonic anhydrase C | Carbonic anhydrase II (CA II) | Carbonic anhydrase II (CA-II) | Carbonic anhydrase II (CAII) | Carbonic anhydrase II (hCA II) | Carbonic anhydrase isoenzyme II (hCA II)
Type:
Enzyme
Mol. Mass.:
29250.71
Organism:
Homo sapiens (Human)
Description:
P00918
Residue:
260
Sequence:
MSHHWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRILNNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHLVHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDPRGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELMVDNWRPAQPLKNRQIKASFK
  
Inhibitor
Name:
BDBM50321257
Synonyms:
5-hydroxy-1-tosyl-1H-pyrrol-2(5H)-one | CA inhibitor, 16 | CHEMBL1163554
Type:
Small organic molecule
Emp. Form.:
C11H11NO4S
Mol. Mass.:
253.274
SMILES:
Cc1ccc(cc1)S(=O)(=O)N1C(O)C=CC1=O |c:14|
Structure:
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