Reaction Details  Report a problem with these data
Target
Adenosine receptor A1
Ligand
BDBM50330621
Substrate
n/a
Meas. Tech.
ChEMBL_685066 (CHEMBL1286682)
Ki
3080±n/a nM
Citation
 Giovannoni, MP; Vergelli, C; Cilibrizzi, A; Crocetti, L; Biancalani, C; Graziano, A; Dal Piaz, V; Loza, MI; Cadavid, MI; Díaz, JL; Gavaldà, A Pyrazolo[1',5':1,6]pyrimido[4,5-d]pyridazin-4(3H)-ones as selective human A(1) adenosine receptor ligands. Bioorg Med Chem 18:7890-9 (2010) [PubMed]  Article
Target
Name:
Adenosine receptor A1
Synonyms:
A1 adenosine receptor (hA1) | A1AR | AA1R_HUMAN | ADENOSINE A1 | ADORA1 | Adenosine A1 receptor (A1AR) | Adenosine A1-receptor | Adenosine receptor A1 (A1) | Adenosine receptor A1 (hA1) | Adenosine transporter (AdT)
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
36520.92
Organism:
Homo sapiens (Human)
Description:
P30542
Residue:
326
Sequence:
MPPSISAFQAAYIGIEVLIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIPLAILINIGPQTYFHTCLMVACPVLILTQSSILALLAIAVDRYLRVKIPLRYKMVVTPRRAAVAIAGCWILSFVVGLTPMFGWNNLSAVERAWAANGSMGEPVIKCEFEKVISMEYMVYFNFFVWVLPPLLLMVLIYLEVFYLIRKQLNKKVSASSGDPQKYYGKELKIAKSLALILFLFALSWLPLHILNCITLFCPSCHKPSILTYIAIFLTHGNSAMNPIVYAFRIQKFRVTFLKIWNDHFRCQPAPPIDEDLPEERPDD
  
Inhibitor
Name:
BDBM50330621
Synonyms:
1,6-Dimethyl-9-phenyl-3-(1-phenylethyl)pyrazolo[1',5':1,6]pyrimido-[4,5-d]pyridazin-4(3H)-one | CHEMBL1277207
Type:
Small organic molecule
Emp. Form.:
C24H21N5O
Mol. Mass.:
395.4564
SMILES:
CC(c1ccccc1)n1nc(C)c2c3cc(nn3c(C)nc2c1=O)-c1ccccc1
Structure:
Search PDB for entries with ligand similarity: