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Target
Aminopeptidase N
Ligand
BDBM50331047
Substrate
n/a
Meas. Tech.
ChEMBL_684892 (CHEMBL1286216)
Ki
11900±n/a nM
Citation
 Andersson, H; Demaegdt, H; Vauquelin, G; Lindeberg, G; Karlén, A; Hallberg, M; Erdélyi, M; Hallberg, A Disulfide cyclized tripeptide analogues of angiotensin IV as potent and selective inhibitors of insulin-regulated aminopeptidase (IRAP). J Med Chem 53:8059-71 (2010) [PubMed]  Article
Target
Name:
Aminopeptidase N
Synonyms:
AMPN_HUMAN | ANPEP | APN | Alanyl aminopeptidase | Aminopeptidase | CD13 | CD_antigen=CD13 | Microsomal aminopeptidase | Myeloid plasma membrane glycoprotein CD13 | PEPN | gp150 | hAPN
Type:
PROTEIN
Mol. Mass.:
109522.63
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1507526
Residue:
967
Sequence:
MAKGFYISKSLGILGILLGVAAVCTIIALSVVYSQEKNKNANSSPVASTTPSASATTNPASATTLDQSKAWNRYRLPNTLKPDSYRVTLRPYLTPNDRGLYVFKGSSTVRFTCKEATDVIIIHSKKLNYTLSQGHRVVLRGVGGSQPPDIDKTELVEPTEYLVVHLKGSLVKDSQYEMDSEFEGELADDLAGFYRSEYMEGNVRKVVATTQMQAADARKSFPCFDEPAMKAEFNITLIHPKDLTALSNMLPKGPSTPLPEDPNWNVTEFHTTPKMSTYLLAFIVSEFDYVEKQASNGVLIRIWARPSAIAAGHGDYALNVTGPILNFFAGHYDTPYPLPKSDQIGLPDFNAGAMENWGLVTYRENSLLFDPLSSSSSNKERVVTVIAHELAHQWFGNLVTIEWWNDLWLNEGFASYVEYLGADYAEPTWNLKDLMVLNDVYRVMAVDALASSHPLSTPASEINTPAQISELFDAISYSKGASVLRMLSSFLSEDVFKQGLASYLHTFAYQNTIYLNLWDHLQEAVNNRSIQLPTTVRDIMNRWTLQMGFPVITVDTSTGTLSQEHFLLDPDSNVTRPSEFNYVWIVPITSIRDGRQQQDYWLIDVRAQNDLFSTSGNEWVLLNLNVTGYYRVNYDEENWRKIQTQLQRDHSAIPVINRAQIINDAFNLASAHKVPVTLALNNTLFLIEERQYMPWEAALSSLSYFKLMFDRSEVYGPMKNYLKKQVTPLFIHFRNNTNNWREIPENLMDQYSEVNAISTACSNGVPECEEMVSGLFKQWMENPNNNPIHPNLRSTVYCNAIAQGGEEEWDFAWEQFRNATLVNEADKLRAALACSKELWILNRYLSYTLNPDLIRKQDATSTIISITNNVIGQGLVWDFVQSNWKKLFNDYGGGSFSFSNLIQAVTRRFSTEYELQQLEQFKKDNEETGFGSGTRALEQALEKTKANIKWVKENKEVVLQWFTENSK
  
Inhibitor
Name:
BDBM50331047
Synonyms:
2-(2-(((5R,9S,12S)-12-amino-9-(4-hydroxybenzyl)-7,11-dioxo-1,2-dithia-6,10-diazacyclotetradecane-5-carboxamido)methyl)phenyl)acetic acid | CHEMBL1277893
Type:
Small organic molecule
Emp. Form.:
C27H34N4O6S2
Mol. Mass.:
574.712
SMILES:
N[C@H]1CCSSCC[C@@H](NC(=O)C[C@H](Cc2ccc(O)cc2)NC1=O)C(=O)NCc1ccccc1CC(O)=O |r|
Structure:
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