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Target
D(3) dopamine receptor
Ligand
BDBM50132057
Substrate
n/a
Meas. Tech.
ChEMBL_687312 (CHEMBL1291988)
Ki
0.33±n/a nM
Citation
 Höfling, SB; Maschauer, S; Hübner, H; Gmeiner, P; Wester, HJ; Prante, O; Heinrich, MR Synthesis, biological evaluation and radiolabelling by 18F-fluoroarylation of a dopamine D3-selective ligand as prospective imaging probe for PET. Bioorg Med Chem Lett 20:6933-7 (2010) [PubMed]  Article
Target
Name:
D(3) dopamine receptor
Synonyms:
DOPAMINE D3 | DRD3 | DRD3_HUMAN | Dopamine D3 receptor | Dopamine D3 receptor (D3) | Dopamine D3 receptor (D3R) | Dopamine receptor | Dopamine receptor (D3) | Dopamine receptor D3
Type:
n/a
Mol. Mass.:
44243.43
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
400
Sequence:
MASLSQLSSHLNYTCGAENSTGASQARPHAYYALSYCALILAIVFGNGLVCMAVLKERALQTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWNFSRICCDVFVTLDVMMCTASILNLCAISIDRYTAVVMPVHYQHGTGQSSCRRVALMITAVWVLAFAVSCPLLFGFNTTGDPTVCSISNPDFVIYSSVVSFYLPFGVTVLVYARIYVVLKQRRRKRILTRQNSQCNSVRPGFPQQTLSPDPAHLELKRYYSICQDTALGGPGFQERGGELKREEKTRNSLSPTIAPKLSLEVRKLSNGRLSTSLKLGPLQPRGVPLREKKATQMVAIVLGAFIVCWLPFFLTHVLNTHCQTCHVSPELYSATTWLGYVNSALNPVIYTTFNIEFRKAFLKILSC
  
Inhibitor
Name:
BDBM50132057
Synonyms:
CHEMBL1180430 | CHEMBL126128 | N-{4-[4-(2-Methoxy-phenyl)-piperazin-1-yl]-butyl}-3-phenyl-acrylamide; oxalic acid
Type:
Small organic molecule
Emp. Form.:
C24H31N3O2
Mol. Mass.:
393.5218
SMILES:
COc1ccccc1N1CCN(CCCCNC(=O)\C=C\c2ccccc2)CC1
Structure:
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