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Target
Polyamine deacetylase HDAC10
Ligand
BDBM50333092
Substrate
n/a
Meas. Tech.
ChEMBL_690179 (CHEMBL1634309)
IC50
1530±n/a nM
Citation
 Auzzas, L; Larsson, A; Matera, R; Baraldi, A; Deschênes-Simard, B; Giannini, G; Cabri, W; Battistuzzi, G; Gallo, G; Ciacci, A; Vesci, L; Pisano, C Non-Natural Macrocyclic Inhibitors of Histone Deacetylases: Design, Synthesis, and Activity J Med Chem 53:8387-8399 (2010) [PubMed]  Article
Target
Name:
Polyamine deacetylase HDAC10
Synonyms:
HD10 | HDA10_HUMAN | HDAC10 | Histone deacetylase | Histone deacetylase 10 | Human HDAC10
Type:
Chromatin regulator; hydrolase; repressor
Mol. Mass.:
71431.89
Organism:
Homo sapiens (Human)
Description:
Q969S8
Residue:
669
Sequence:
MGTALVYHEDMTATRLLWDDPECEIERPERLTAALDRLRQRGLEQRCLRLSAREASEEELGLVHSPEYVSLVRETQVLGKEELQALSGQFDAIYFHPSTFHCARLAAGAGLQLVDAVLTGAVQNGLALVRPPGHHGQRAAANGFCVFNNVAIAAAHAKQKHGLHRILVVDWDVHHGQGIQYLFEDDPSVLYFSWHRYEHGRFWPFLRESDADAVGRGQGLGFTVNLPWNQVGMGNADYVAAFLHLLLPLAFEFDPELVLVSAGFDSAIGDPEGQMQATPECFAHLTQLLQVLAGGRVCAVLEGGYHLESLAESVCMTVQTLLGDPAPPLSGPMAPCQSALESIQSARAAQAPHWKSLQQQDVTAVPMSPSSHSPEGRPPPLLPGGPVCKAAASAPSSLLDQPCLCPAPSVRTAVALTTPDITLVLPPDVIQQEASALREETEAWARPHESLAREEALTALGKLLYLLDGMLDGQVNSGIAATPASAAAATLDVAVRRGLSHGAQRLLCVALGQLDRPPDLAHDGRSLWLNIRGKEAAALSMFHVSTPLPVMTGGFLSCILGLVLPLAYGFQPDLVLVALGPGHGLQGPHAALLAAMLRGLAGGRVLALLEENSTPQLAGILARVLNGEAPPSLGPSSVASPEDVQALMYLRGQLEPQWKMLQCHPHLVA
  
Inhibitor
Name:
BDBM50333092
Synonyms:
(R/S)-6-(6-Oxo-6,7,9,10,11,12-hexahydro-5H-8,13-dioxa-5-azabenzocycloundecen-7-yl)hexanoic acid hydroxyamide | CHEMBL1631910
Type:
Small organic molecule
Emp. Form.:
C19H28N2O5
Mol. Mass.:
364.436
SMILES:
ONC(=O)CCCCCC1OCCCCCOc2ccccc2NC1=O
Structure:
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