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Target
Pkd1
Ligand
BDBM50337697
Substrate
n/a
Meas. Tech.
ChEMBL_728827 (CHEMBL1686362)
EC50
530±n/a nM
Citation
 Gamber, GG; Meredith, E; Zhu, Q; Yan, W; Rao, C; Capparelli, M; Burgis, R; Enyedy, I; Zhang, JH; Soldermann, N; Beattie, K; Rozhitskaya, O; Koch, KA; Pagratis, N; Hosagrahara, V; Vega, RB; McKinsey, TA; Monovich, L 3,5-diarylazoles as novel and selective inhibitors of protein kinase D. Bioorg Med Chem Lett 21:1447-51 (2011) [PubMed]  Article
Target
Name:
Pkd1
Synonyms:
n/a
Type:
PROTEIN
Mol. Mass.:
465365.77
Organism:
Rattus norvegicus
Description:
ChEMBL_103934
Residue:
4283
Sequence:
ALALGLGLWLGALAGDPGRGCGPCPLPCFCSPAPDAACRVNCSGRWLQTLGPSLRIPADATALDLSHNLLQTLDIRLLVNLSGLVELDLSNNRISTLEEGVFANLFNLSEINLSGNPFECNCGLAWLPRWAKEQQVHVVQSEATTCRGPVPLAGRPLLSTPLLDNACGEEYVACLPDNSSGAVAAVPFFFAHQGPLETAACSAFCFSAGEGLAALSEQNQCLCGAGQPSNTSAACSSWCSSILLSFNSACGGPTLLQHTFPASPGAALVGPHGPLASGQPADFHINSPLPISSTCWNFGDGSPEVDMAGPAATHSYVLPGGYHVTVVLTLGAGSALLETEVQVEVAPTVLELVCPSFVHSDESLDLGIRHRGGSALEVTYSILALDKEPAQVVHPLCPSDTEIFPGNGHCYRLVAEKAPWLQAQEQCRTWAGAALAMVDSPAIQHFLVSKVTRSLDVWIGFSSVEGKEGLDPQGEAFSLESCQNWLPGEPHPATEEHCVRLGPAGQCNTDLCSAPHSYVCELRPGGPVGDADNFLLGVSGGGRSGPLQPLAQQGTLQGPLQPVEVMVFPGLSPSREAFLTAAEFETQELEDPVQLRLQVYRHSREAVAPEGSSELDNSTEPAPKCVPEELWCPGANVCVPFDALCNSHVCINGSASRLGLPRASYTLWKEFFFSVPAGPPTQYLVTLHGQDVPMLPGDLVALQHDAGPGTFLHCPLASSCPGQALYLSTNASDWMTNLPVHLEEAWAGPVCSLQLLLVTEQLTPLLGLGSNPGLQHPGHYEVRATVGNSISRQNLSCSFSVVSPVAGLRVIHPIPLDGHIYVPTNGSILVLQVDSGANATATAHWFGGNVSAPFEDACPPEVDFLKQDCTEEANATLFSVLVLPRLKEGDHTVEIVAQNGASQANLSLRVTAEEPICGLRAVPSPEARVLQGILVRYSPMVEAGSDVAFRWTIDDKQSLTFHNTVFNVIYQTAAVFKLSLTASNHVSNITVNYNVTVERMNKMHGLWVSAVPAVLPPNATLALTGGVLVDSAVEVAFLWNFGDGEQVLRQFKPPYDESFQVPDPTVAQVLVEHNTTHIYNTPGEYNLTVTVSNTYENLTQQVPVSVRTVLPNVTIGMSSNVLLAGQPITFFPYPLPSADGVLYTWDFGDGSPVLIQSQPVLNHTYSMTGTYRISLEVNNTVSSVAAHVDICVFQELHGLTVYLNQSVEQGAPMVVNASVESGDNITWTFDMGDGTVFTGPEATVEHVYLRAQNFTVTVGATSPAGHLSQSLHVQVFVLEVLRIEPSTCIPTQPSAQIMAHVTGDPAHYLFDWTFGDGSSNVTVHGHPSVTHNFTRSGIFPLALVLSSHVNKAHYFTSICVEPEICNVTLQPERQVVKLGDEAWLVAYPWPPFPYRYTWDFGTEDSIHTQTGGSEVTFIYREPGSYLVIVTVSNNISSTNDSAFVDVQEPVSVTGIRINGSHVLELQQPYLFSAMGNGSPAAYLWELGDGSQHEGPEVTHIYSSTGDFTVRVSGWNEVSRSEAQLNITVKQRVRGLTINASPTVVPLNGSVSFSTLLEVGSDVHYSWVLCDRCTPIPGGPTISYTFRSVGTFNIIVTAENEVGSAQDSIFIYVLQLIEGLQVVGGDGGCCFPTNYTLQLQAAVRDGTNISYSWTAQQDGGPTLISSGKSFSLTALKASTYYVHLRATNMLGSASANRTIDFVEPVESLILSASPNPAAVNTSLTLGAELAGGSGVVYTWYLEEGLSRETSMPSTTHTFAAPGLHLVRVTAENQLGSVNATIEVAVHGPVGGLSIRTSEPDSIFVAAGSTVPFWGQLAEGTNVTWCWTLPGGSKYSQYIDVRFPAAGHFSLWLNASNAVSWVSAVYNLTVEEPIMNLVLWASSKVVAPGQPVHFQILLAAGSAVTFRLQVGGSIPEVLPSLHFSHSFFRVGDHMVSVQAENHVSRAQAQVRILVLEAIVGLQVPNCCEPGMATGTEKNFTARVQRGSRVAYAWYFSLQKVQGDSLVILSGRDVTYTPVAAGILEIHVRAFNELGGVNLTLVVEVQDIIQYVTLQSGRCFTNRSARFEAATSPSPRRVTYHWDFGDGTPVQETEESWTDHYYLHPGDYRVEVNATNLVSFFVAQAQVTVQVLACREPEVEVALPLQVLMRRSQRNYLEAHVDLRNCVSYQTEYRWEVYRTTSCQRAGRMTQMVLPGVDVSRPQLVVPRLALPVGHYCFVFVVSFGDTPLARSIQANVTVAAERLVPIIEGGSYRVWSDTQDLVLDGSKSYDPNLEDGDQTPLNFHWACVASTQSETGGCVLKLWARGSSVVTIPLERLEAGVEYTFNLIVWKAGRKEEATNQTVLIRSGRVPIVSLECVSCKAQAVYEVSRSSYVYLEGHCHNCSSGSKQGRWAARTFSNKTLMLNENTTSTGSTGMHLVVRPGALHDGEGYIFTLTVLGHSGEEEGCRSIRLLPNRPPLGGSCRLFPLESVRGLTTKVHFECTGWRDAEDGGAPLVYALRLKRCHQNYCEDFCIYKGSLSTYGAVLPPGFQPLFVVSLTVVVEDQLGASVVALNRSLTIVLPEPSGNPADLIPWLHSLTASVLPGLLRQADPQHVIEYSLALITVLNEYEQAPDMVSEPNLEQQLRAQMRKNITETLISLRVNTVDDIQQITAALAQCMVSSRELMCRSCLKKMLQKLEGMMRILQAETTEGTLTPTTIADSILNITGDLIHLASLDMQGPQPLELGAEPPSLMVASKAYNLSSALMCILMRSRVLNEEPLTLAGEEIVALGKRADPLSLLCYGKAWGPSCHFSIPEAFSGALSDLSDVVQLILLVDSNPFPFGYISNYTVSTKVASMAFQTQTGTQIPIEQLAADGSITVKVPNNSDQAAQSSHSPVGSTIVQPRASVSAVVTADNSNPQAGLHLRITYTVLNARYLSEEREPYLAVYLHSVSQPNEYNCSASRRISLEVLEGADHRPYTFFIAPGTGTLGRSYYLNLTSHFHWSALEVSVGLYTSLCQYFSEEAMMWRTEGIVPLEETSPSQAVCLTRHLTAFGASLFVPPSHVQFIFPEPSVSINYIVLLTCVICLVTYVIMAMILRKLDQLDVSRVRVIPFCGKGGRFKYEILVKTGWSRGSGTTAHVGIMLYGEDNRSGHRHLDGDRAFHRNSLDIFQIATPQSLGSVWKIRVWHDNKGLSPAWFLQHIIVRDLQSARSTFFLVNDWLSVETEANGGLVEKEVLAANEAALWQFQRLLVAELQRGFFDKHIWLSIWDRPPRSRFTRVQRVTCCVLLLCLFLAANAVWYGVVGDTTYSMGPVSSLMSPSVDTVAIGLVSSVVVYPVYLAVLFLFRMSRSKVSGDQNPTPTGQQALDVDSYLDPSVLDSSLLTLSGLTEAFSGQVKNDLFLEDAKSLVCWPSSEGTLSWPDLLSDPSVMSSTLQRLAQGRPGCMLGSEEDGASLVSPSLPAKYLSASDEDLIHQVLADGANNPDPTQDALIERDLLTSLSSAPGEKTETLILQTMGEKRPPSMGLTWEQSPVTRLSRTGLVEGLRKRLLPTWCAPLAHGLSLLLVAVAVAVSGWIGASFPPSVSVMWLLSSSSSFLASFLGWEPLKVLLEALYFSLVAKRLHPDEDDTLVESPAVTPVSERVPRVRPPHGFALFLAKEEARKVKRLHDMLKSLLVYMLFLLVTLLANYGDASCHGHAYRLQSAIKQELDSQAFLAITRSDEFWPWMSHVLLPYVHGNQSSPELGPPRLRQVRLQEAFCPDPSSSEHMCSATGSLSTSDYGIGWQSVVQNGSETWAYSAPDLLGAWYWGYCAVYDSGGYIQELGLSLEESRARLGFLQLHNWLDSRSRAVFVELTRYSPAVGLHAAVTLRLEFPVAGHALAAFSVRPFALRRLSTGLSLPLLTSVCLLLFALYFSVAEVHTWRREGCARTARPDVGARWLLVMLTAATGLVRLAQLRIADRQWTRFVHDHPHHFTSFDQVAQLGSVARGLAASLLFLLLVKAAQHVRFVRQWSVFGKTLCRALPELMGATLGLVLLGVAYAQMAILLISSGADTLYSMARAFLVLCPGARVPTLCPSESWYLSPLLCVGLWALRVWGALRLGAVLLRWRYHALRGELYRPAWEPQDYEMVELFLRRLRLWMGFTKVKEFRHKVRFEGMDPLPSRSSRGSKSSPVVPPPSAGSEASHPSTSSSQPDGLSAGLRRSALRLEPEPSRLHAVFESLLVQFDRLNQATEDVYQLEQQLQSLRGHGHSGPPSSPSPGGFPASQPALPSRLARASQGPDQTTGPSRVSLWPNNKVHPSST
  
Inhibitor
Name:
BDBM50337697
Synonyms:
(R)-N-(1-cyanoethyl)-3-(5-(4-((isopropylamino)methyl)phenyl)-1H-pyrazol-3-yl)benzamide | CHEMBL1683435
Type:
Small organic molecule
Emp. Form.:
C23H25N5O
Mol. Mass.:
387.4775
SMILES:
CC(C)NCc1ccc(cc1)-c1cc([nH]n1)-c1cccc(c1)C(=O)N[C@H](C)C#N |r|
Structure:
Search PDB for entries with ligand similarity: