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Target
Delta-type opioid receptor
Ligand
BDBM50339236
Substrate
n/a
Meas. Tech.
ChEMBL_736202 (CHEMBL1693238)
Ki
96±n/a nM
Citation
 Mallareddy, JR; Borics, A; Keresztes, A; Kövér, KE; Tourwé, D; Tóth, G Design, synthesis, pharmacological evaluation, and structure-activity study of novel endomorphin analogues with multiple structural modifications. J Med Chem 54:1462-72 (2011) [PubMed]  Article
Target
Name:
Delta-type opioid receptor
Synonyms:
Cytochrome P450 3A4 | DOR-1 | Delta opioid receptor | Delta-type opioid receptor | Delta-type opioid receptor (DOR) | OPIATE Delta | OPRD_RAT | Opiate Delta 1 | Opioid receptor | Opioid receptor A | Opioid receptors; mu & delta | Oprd1 | Ror-a | Voltage-gated potassium channel
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
40465.04
Organism:
Rattus norvegicus (rat)
Description:
Competition binding assays were using CHO-K1 cell membranes expressing the opioid receptor.
Residue:
372
Sequence:
MEPVPSARAELQFSLLANVSDTFPSAFPSASANASGSPGARSASSLALAIAITALYSAVCAVGLLGNVLVMFGIVRYTKLKTATNIYIFNLALADALATSTLPFQSAKYLMETWPFGELLCKAVLSIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPAKAKLINICIWVLASGVGVPIMVMAVTQPRDGAVVCTLQFPSPSWYWDTVTKICVFLFAFVVPILIITVCYGLMLLRLRSVRLLSGSKEKDRSLRRITRMVLVVVGAFVVCWAPIHIFVIVWTLVDINRRDPLVVAALHLCIALGYANSSLNPVLYAFLDENFKRCFRQLCRAPCGGQEPGSLRRPRQATARERVTACTPSDGPGGGAAA
  
Inhibitor
Name:
BDBM50339236
Synonyms:
(1S,2R)-N-((2S)-1-(1-amino-3-(4-fluorophenyl)-1-oxopropan-2-ylamino)-1-oxo-3-phenylpropan-2-yl)-2-(2-amino-3-(4-hydroxy-3,5-dimethylphenyl)propanamido)cyclohexanecarboxamide | CHEMBL1689552
Type:
Small organic molecule
Emp. Form.:
C36H44FN5O5
Mol. Mass.:
645.7635
SMILES:
Cc1cc(CC(N)C(=O)N[C@@H]2CCCC[C@@H]2C(=O)N[C@@H](Cc2ccccc2)C(=O)NC(Cc2ccc(F)cc2)C(N)=O)cc(C)c1O |r|
Structure:
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