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Target
Phospho-N-acetylmuramoyl-pentapeptide-transferase
Ligand
BDBM50342787
Substrate
n/a
Meas. Tech.
ChEMBL_744419 (CHEMBL1772373)
IC50
1600000±n/a nM
Citation
 Mravljak, J; Monasson, O; Al-Dabbagh, B; Crouvoisier, M; Bouhss, A; Gravier-Pelletier, C; Le Merrer, Y Synthesis and biological evaluation of a diazepanone-based library of liposidomycins analogs as MraY inhibitors. Eur J Med Chem 46:1582-92 (2011) [PubMed]  Article
Target
Name:
Phospho-N-acetylmuramoyl-pentapeptide-transferase
Synonyms:
MRAY_STAAU | mraY
Type:
PROTEIN
Mol. Mass.:
35238.55
Organism:
Staphylococcus aureus (strain MRSA252)
Description:
ChEMBL_827497
Residue:
321
Sequence:
MIFVYALLALVITFVLVPVLIPTLKRMKFGQSIREEGPQSHMKKTGTPTMGGLTFLLSIVITSLVAIIFVDQANPIILLLFVTIGFGLIGFIDDYIIVVKKNNQGLTSKQKFLAQIGIAIIFFVLSNVFHLVNFSTSIHIPFTNVAIPLSFAYVIFIVFWQVGFSNAVNLTDGLDGLATGLSIIGFTMYAIMSFVLGETAIGIFCIIMLFALLGFLPYNINPAKVFMGDTGSLALGGIFATISIMLNQELSLIFIGLVFVIETLSVMLQVASFKLTGKRIFKMSPIHHHFELIGWSEWKVVTVFWAVGLISGLIGLWIGVH
  
Inhibitor
Name:
BDBM50342787
Synonyms:
(3S,6S,7R)-3-(Benzyloxymethyl)-7-(tertbutyldiphenylsilyloxymethyl)-4-N-(5''-(uracil-1'-yl)pentyl)-6-hydroxy-1,4-diazepan-2-one | CHEMBL1770410
Type:
Small organic molecule
Emp. Form.:
C38H48N4O6Si
Mol. Mass.:
684.8964
SMILES:
CC(C)(C)[Si](OC[C@H]1NC(=O)[C@H](COCc2ccccc2)N(CCCCn2ccc(=O)[nH]c2=O)C[C@@H]1O)(c1ccccc1)c1ccccc1 |r|
Structure:
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