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Target
Melatonin receptor type 1A
Ligand
BDBM50343989
Substrate
n/a
Meas. Tech.
ChEMBL_748407 (CHEMBL1781571)
EC50
>10000±n/a nM
Citation
 Mésangeau, C; Fraise, M; Delagrange, P; Caignard, DH; Boutin, JA; Berthelot, P; Yous, S Preparation and pharmacological evaluation of a novel series of 2-(phenylthio)benzo[b]thiophenes as selective MT2 receptor ligands. Eur J Med Chem 46:1835-40 (2011) [PubMed]  Article
Target
Name:
Melatonin receptor type 1A
Synonyms:
MTNR1A | MTNR1A protein | MTR1A_HUMAN | Mel-1A-R | Mel1a melatonin receptor | Melatonin 1A | Melatonin receptor | Melatonin receptor 1A | Melatonin receptor type 1 (MT1) | Melatonin receptor type 1A
Type:
Enzyme
Mol. Mass.:
39392.94
Organism:
Homo sapiens (Human)
Description:
P48039
Residue:
350
Sequence:
MQGNGSALPNASQPVLRGDGARPSWLASALACVLIFTIVVDILGNLLVILSVYRNKKLRNAGNIFVVSLAVADLVVAIYPYPLVLMSIFNNGWNLGYLHCQVSGFLMGLSVIGSIFNITGIAINRYCYICHSLKYDKLYSSKNSLCYVLLIWLLTLAAVLPNLRAGTLQYDPRIYSCTFAQSVSSAYTIAVVVFHFLVPMIIVIFCYLRIWILVLQVRQRVKPDRKPKLKPQDFRNFVTMFVVFVLFAICWAPLNFIGLAVASDPASMVPRIPEWLFVASYYMAYFNSCLNAIIYGLLNQNFRKEYRRIIVSLCTARVFFVDSSNDVADRVKWKPSPLMTNNNVVKVDSV
  
Inhibitor
Name:
BDBM50343989
Synonyms:
CHEMBL1779807 | N-(2-(5-fluoro-2-(4-fluorophenylthio)benzo[b]thiophen-3-yl)ethyl)bromoacetamide
Type:
Small organic molecule
Emp. Form.:
C18H14BrF2NOS2
Mol. Mass.:
442.341
SMILES:
Fc1ccc(Sc2sc3ccc(F)cc3c2CCNC(=O)CBr)cc1
Structure:
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