Reaction Details  Report a problem with these data
Target
Alpha-2B adrenergic receptor
Ligand
BDBM50366618
Substrate
n/a
Meas. Tech.
ChEBML_33795
Ki
1088±n/a nM
Citation
 Marzabadi, MR; Hong, X; Nagarathnam, D; Miao, SW; Chiu, G; Wong, WC; Wetzel, JM; Fang, J; Forray, C; Chen, TB; O'Malley, SS; Chang, RS; Gluchowski, C Design and synthesis of novel dihydropyridine alpha-1a antagonists. Bioorg Med Chem Lett 9:2843-8 (1999) [PubMed]
Target
Name:
Alpha-2B adrenergic receptor
Synonyms:
ADA2B_HUMAN | ADRA2B | ADRA2L1 | ADRA2RL1 | Adrenergic alpha2B | Adrenergic receptor | Adrenergic receptor alpha | Adrenergic, alpha-2B-, receptor [Homo sapiens] | Alpha-2 adrenergic receptor subtype C2 | Alpha-2B adrenoceptor | Alpha-2B adrenoreceptor | Alpha-2BAR
Type:
Enzyme
Mol. Mass.:
49964.20
Organism:
Homo sapiens (Human)
Description:
P18089
Residue:
450
Sequence:
MDHQDPYSVQATAAIAAAITFLILFTIFGNALVILAVLTSRSLRAPQNLFLVSLAAADILVATLIIPFSLANELLGYWYFRRTWCEVYLALDVLFCTSSIVHLCAISLDRYWAVSRALEYNSKRTPRRIKCIILTVWLIAAVISLPPLIYKGDQGPQPRGRPQCKLNQEAWYILASSIGSFFAPCLIMILVYLRIYLIAKRSNRRGPRAKGGPGQGESKQPRPDHGGALASAKLPALASVASAREVNGHSKSTGEKEEGETPEDTGTRALPPSWAALPNSGQGQKEGVCGASPEDEAEEEEEEEEEEEECEPQAVPVSPASACSPPLQQPQGSRVLATLRGQVLLGRGVGAIGGQWWRRRAQLTREKRFTFVLAVVIGVFVLCWFPFFFSYSLGAICPKHCKVPHGLFQFFFWIGYCNSSLNPVIYTIFNQDFRRAFRRILCRPWTQTAW
  
Inhibitor
Name:
BDBM50366618
Synonyms:
CHEMBL448620 | SNAP-5089
Type:
Small organic molecule
Emp. Form.:
C36H40N4O5
Mol. Mass.:
608.7266
SMILES:
COC(=O)C1C(C(C(=O)NCCCN2CCC(CC2)(c2ccccc2)c2ccccc2)=C(C)N=C1C)c1ccc(cc1)[N+]([O-])=O |c:36,t:33|
Structure:
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