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Target
Excitatory amino acid transporter 3
Ligand
BDBM50247191
Substrate
n/a
Meas. Tech.
ChEMBL_68329 (CHEMBL680700)
IC50
8000±n/a nM
Citation
 Shimamoto, K; Shigeri, Y; Yasuda-Kamatani, Y; Lebrun, B; Yumoto, N; Nakajima, T Syntheses of optically pure beta-hydroxyaspartate derivatives as glutamate transporter blockers. Bioorg Med Chem Lett 10:2407-10 (2001) [PubMed]
Target
Name:
Excitatory amino acid transporter 3
Synonyms:
EAA3_HUMAN | EAAC1 | EAAT3 | Excitatory Amino Acid EAAT3 | HEAAC1 | SLC1A1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
57096.71
Organism:
Homo sapiens (Human)
Description:
Excitatory Amino Acid EAAT3 0 HUMAN::P43005
Residue:
524
Sequence:
MGKPARKGCEWKRFLKNNWVLLSTVAAVVLGITTGVLVREHSNLSTLEKFYFAFPGEILMRMLKLIILPLIISSMITGVAALDSNVSGKIGLRAVVYYFCTTLIAVILGIVLVVSIKPGVTQKVGEIARTGSTPEVSTVDAMLDLIRNMFPENLVQACFQQYKTKREEVKPPSDPEMNMTEESFTAVMTTAISKNKTKEYKIVGMYSDGINVLGLIVFCLVFGLVIGKMGEKGQILVDFFNALSDATMKIVQIIMCYMPLGILFLIAGKIIEVEDWEIFRKLGLYMATVLTGLAIHSIVILPLIYFIVVRKNPFRFAMGMAQALLTALMISSSSATLPVTFRCAEENNQVDKRITRFVLPVGATINMDGTALYEAVAAVFIAQLNDLDLGIGQIITISITATSASIGAAGVPQAGLVTMVIVLSAVGLPAEDVTLIIAVDWLLDRFRTMVNVLGDAFGTGIVEKLSKKELEQMDVSSEVNIVNPFALESTILDNEDSDTKKSYVNGGFAVDKSDTISFTQTSQF
  
Inhibitor
Name:
BDBM50247191
Synonyms:
(2S,3S)-2-Amino-3-benzyloxy-succinic acid | CHEMBL475341 | D,L-threo-beta-benzyloxyaspartate | DL-2-amino-3-(benzyloxy)succinic acid | DL-threo-beta-benzyloxyaspartate
Type:
Small organic molecule
Emp. Form.:
C11H13NO5
Mol. Mass.:
239.2246
SMILES:
NC(C(OCc1ccccc1)C(O)=O)C(O)=O
Structure:
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