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Target
Gastrin/cholecystokinin type B receptor
Ligand
BDBM50008170
Substrate
n/a
Meas. Tech.
ChEBML_48110
IC50
1900±n/a nM
Citation
 Freidinger, RM; Whitter, WL; Gould, NP; Holloway, MK; Chang, RS; Lotti, VJ Novel glutamic acid derived cholecystokinin receptor ligands. J Med Chem 33:591-5 (1990) [PubMed]
Target
Name:
Gastrin/cholecystokinin type B receptor
Synonyms:
CCK-2 receptor | CCK-B receptor | CCK-BR | CCKBR | CCKRB | Cholecystokinin A | Cholecystokinin receptor | Cholecystokinin-2 Receptor | GASR_HUMAN | Gastrin/cholecystokinin type B receptor
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
48445.79
Organism:
Homo sapiens (Human)
Description:
Stable expression of human CCK-2 receptors in HEK 293 cells.
Residue:
447
Sequence:
MELLKLNRSVQGTGPGPGASLCRPGAPLLNSSSVGNLSCEPPRIRGAGTRELELAIRITLYAVIFLMSVGGNMLIIVVLGLSRRLRTVTNAFLLSLAVSDLLLAVACMPFTLLPNLMGTFIFGTVICKAVSYLMGVSVSVSTLSLVAIALERYSAICRPLQARVWQTRSHAARVIVATWLLSGLLMVPYPVYTVVQPVGPRVLQCVHRWPSARVRQTWSVLLLLLLFFIPGVVMAVAYGLISRELYLGLRFDGDSDSDSQSRVRNQGGLPGAVHQNGRCRPETGAVGEDSDGCYVQLPRSRPALELTALTAPGPGSGSRPTQAKLLAKKRVVRMLLVIVVLFFLCWLPVYSANTWRAFDGPGAHRALSGAPISFIHLLSYASACVNPLVYCFMHRRFRQACLETCARCCPRPPRARPRALPDEDPPTPSIASLSRLSYTTISTLGPG
  
Inhibitor
Name:
BDBM50008170
Synonyms:
4-(3,4-Dichloro-benzoylamino)-4-dipentylcarbamoyl-butyric acid | CHEMBL24938 | Lorglumide
Type:
Small organic molecule
Emp. Form.:
C22H32Cl2N2O4
Mol. Mass.:
459.406
SMILES:
CCCCCN(CCCCC)C(=O)C(CCC(O)=O)NC(=O)c1ccc(Cl)c(Cl)c1
Structure:
Search PDB for entries with ligand similarity: