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Target
Matrilysin
Ligand
BDBM50084293
Substrate
n/a
Meas. Tech.
ChEMBL_104915 (CHEMBL713451)
IC50
7500±n/a nM
Citation
 O'Brien, PM; Ortwine, DF; Pavlovsky, AG; Picard, JA; Sliskovic, DR; Roth, BD; Dyer, RD; Johnson, LL; Man, CF; Hallak, H Structure-activity relationships and pharmacokinetic analysis for a series of potent, systemically available biphenylsulfonamide matrix metalloproteinase inhibitors. J Med Chem 43:156-66 (2000) [PubMed]
Target
Name:
Matrilysin
Synonyms:
MMP7 | MMP7_HUMAN | MPSL1 | Matrix metalloproteinase 7 | Matrix metalloproteinase-7 (MMP-7) | Matrix metalloproteinase-7 (MMP7) | PUMP1
Type:
Enzyme
Mol. Mass.:
29681.54
Organism:
Homo sapiens (Human)
Description:
P09237
Residue:
267
Sequence:
MRLTVLCAVCLLPGSLALPLPQEAGGMSELQWEQAQDYLKRFYLYDSETKNANSLEAKLKEMQKFFGLPITGMLNSRVIEIMQKPRCGVPDVAEYSLFPNSPKWTSKVVTYRIVSYTRDLPHITVDRLVSKALNMWGKEIPLHFRKVVWGTADIMIGFARGAHGDSYPFDGPGNTLAHAFAPGTGLGGDAHFDEDERWTDGSSLGINFLYAATHELGHSLGMGHSSDPNAVMYPTYGNGDPQNFKLSQDDIKGIQKLYGKRSNSRKK
  
Inhibitor
Name:
BDBM50084293
Synonyms:
(S)-2-(4'-chloro-biphenyl-4-sulfonylamino)-3-methyl-butyric acid | 2-(4'-Chloro-biphenyl-4-sulfonylamino)-3-methyl-butyric acid | CHEMBL296196
Type:
Small organic molecule
Emp. Form.:
C17H18ClNO4S
Mol. Mass.:
367.847
SMILES:
CC(C)[C@H](NS(=O)(=O)c1ccc(cc1)-c1ccc(Cl)cc1)C(O)=O
Structure:
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