Reaction Details  Report a problem with these data
Target
Peptidyl-prolyl cis-trans isomerase FKBP4
Ligand
BDBM50118067
Substrate
n/a
Meas. Tech.
ChEMBL_154482 (CHEMBL882313)
Kd
20000±n/a nM
Citation
 Demange, L; Moutiez, M; Dugave, C Synthesis and evaluation of Glypsi(PO(2)R-N)Pro-containing pseudopeptides as novel inhibitors of the human cyclophilin hCyp-18. J Med Chem 45:3928-33 (2002) [PubMed]
Target
Name:
Peptidyl-prolyl cis-trans isomerase FKBP4
Synonyms:
FK506 binding protein 4 | FKBP4 | FKBP4_HUMAN | FKBP52
Type:
PROTEIN
Mol. Mass.:
51793.87
Organism:
Homo sapiens (Human)
Description:
ChEMBL_154482
Residue:
459
Sequence:
MTAEEMKATESGAQSAPLPMEGVDISPKQDEGVLKVIKREGTGTEMPMIGDRVFVHYTGWLLDGTKFDSSLDRKDKFSFDLGKGEVIKAWDIAIATMKVGEVCHITCKPEYAYGSAGSPPKIPPNATLVFEVELFEFKGEDLTEEEDGGIIRRIQTRGEGYAKPNEGAIVEVALEGYYKDKLFDQRELRFEIGEGENLDLPYGLERAIQRMEKGEHSIVYLKPSYAFGSVGKEKFQIPPNAELKYELHLKSFEKAKESWEMNSEEKLEQSTIVKERGTVYFKEGKYKQALLQYKKIVSWLEYESSFSNEEAQKAQALRLASHLNLAMCHLKLQAFSAAIESCNKALELDSNNEKGLFRRGEAHLAVNDFELARADFQKVLQLYPNNKAAKTQLAVCQQRIRRQLAREKKLYANMFERLAEEENKAKAEASSGDHPTDTEMKEEQKSNTAGSQSQVETEA
  
Inhibitor
Name:
BDBM50118067
Synonyms:
CHEMBL126888 | N-{1-[(Ethoxy-{2-[1-(4-nitro-phenylcarbamoyl)-2-phenyl-ethylcarbamoyl]-pyrrolidin-1-yl}-phosphinoylmethyl)-carbamoyl]-ethyl}-succinamic acid
Type:
Small organic molecule
Emp. Form.:
C30H39N6O10P
Mol. Mass.:
674.6386
SMILES:
CCOP(=O)(CNC(=O)[C@H](C)NC(=O)CCC(O)=O)N1CCCC1C(=O)N[C@@H](Cc1ccccc1)C(=O)Nc1ccc(cc1)[N+]([O-])=O
Structure:
Search PDB for entries with ligand similarity: