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Target
Cytochrome P450 2D3
Ligand
BDBM36108
Substrate
n/a
Meas. Tech.
ChEMBL_51711 (CHEMBL665726)
IC50
155000±n/a nM
Citation
 Venhorst, J; ter Laak, AM; Commandeur, JN; Funae, Y; Hiroi, T; Vermeulen, NP Homology modeling of rat and human cytochrome P450 2D (CYP2D) isoforms and computational rationalization of experimental ligand-binding specificities. J Med Chem 46:74-86 (2002) [PubMed]  Article
Target
Name:
Cytochrome P450 2D3
Synonyms:
CP2D3_RAT | Cyp2d-3 | Cyp2d3
Type:
PROTEIN
Mol. Mass.:
56643.68
Organism:
Rattus norvegicus
Description:
ChEMBL_51711
Residue:
500
Sequence:
MELLAGTGLWPMAIFTVIFILLVDLMHRRQRWTSRYPPGPVPWPVLGNLLQVDLCNMPYSMYKLQNRYGDVFSLQMGWKPVVVINGLKAVQELLVTCGEDTADRPEMPIFQHIGYGHKAKGVVLAPYGPEWREQRRFSVSTLRNFGVGKKSLEQWVTDEASHLCDALTAEAGRPLDPYTLLNKAVCNVIASLIYARRFDYGDPDFIKVLKILKESMGEQTGLFPEVLNMFPVLLRIPGLADKVFPGQKTFLTMVDNLVTEHKKTWDPDQPPRDLTDAFLAEIEKAKGNPESSFNDANLRLVVNDLFGAGMVTTSITLTWALLLMILHPDVQCRVQQEIDEVIGQVRHPEMADQAHMPFTNAVIHEVQRFADIVPMNLPHKTSRDIEVQGFLIPKGTTLIPNLSSVLKDETVWEKPLRFHPEHFLDAQGNFVKHEAFMPFSAGRRACLGEPLARMELFLFFTCLLQRFSFSVPTGQPRPSDYGVFAFLLSPSPYQLCAFKR
  
Inhibitor
Name:
BDBM36108
Synonyms:
(R)-propranolol
Type:
Guest
Emp. Form.:
C16H22NO2
Mol. Mass.:
260.3508
SMILES:
CC(C)[NH2+]C[C@@H](O)COc1cccc2ccccc12
Structure:
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