Reaction Details  Report a problem with these data
Target
Hypoxanthine-guanine phosphoribosyltransferase
Ligand
BDBM12581
Substrate
n/a
Meas. Tech.
ChEMBL_302489 (CHEMBL827179)
Ki
50600±n/a nM
Citation
 Fernández, D; Wenck, MA; Craig, SP; Delfino, JM The purine transferase from Trypanosoma cruzi as a potential target for bisphosphonate-based chemotherapeutic compounds. Bioorg Med Chem Lett 14:4501-4 (2004) [PubMed]  Article
Target
Name:
Hypoxanthine-guanine phosphoribosyltransferase
Synonyms:
HGPRT | HPRT_TRYBB
Type:
PROTEIN
Mol. Mass.:
23360.10
Organism:
Trypanosoma brucei brucei
Description:
ChEMBL_302489
Residue:
210
Sequence:
MEPACKYDFATSVLFTEAELHTRMRGVAQRIADDYSNCNLKPLENPLVIVSVLKGSFVFTADMVRILGDFGVPTRVEFLRASSYGHDTKSCGRVDVKADGLCDIRGKHVLVLEDILDTALTLREVVDSLKKSEPASIKTLVAIDKPGGRKIPFTAEYVVADVPNVFVVGYGLDYDQSYREVRDVVILKPSVYETWGKELERRKAAGEAKR
  
Inhibitor
Name:
BDBM12581
Synonyms:
(3-amino-1-hydroxy-1-phosphonopropyl)phosphonic acid | Bisphosphonate 6 | CHEMBL834 | JMC515594 Compound 62
Type:
Small organic molecule
Emp. Form.:
C3H11NO7P2
Mol. Mass.:
235.0695
SMILES:
NCCC(O)(P(O)(O)=O)P(O)(O)=O
Structure:
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