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Target
3-hydroxyacyl-[acyl-carrier-protein] dehydratase
Ligand
BDBM7457
Substrate
n/a
Meas. Tech.
ChEMBL_361103 (CHEMBL859169)
IC50
2000±n/a nM
Citation
 Tasdemir, D; Lack, G; Brun, R; Rüedi, P; Scapozza, L; Perozzo, R Inhibition of Plasmodium falciparum fatty acid biosynthesis: evaluation of FabG, FabZ, and FabI as drug targets for flavonoids. J Med Chem 49:3345-53 (2006) [PubMed]  Article
Target
Name:
3-hydroxyacyl-[acyl-carrier-protein] dehydratase
Synonyms:
Fatty acid synthase
Type:
PROTEIN
Mol. Mass.:
26222.50
Organism:
Plasmodium falciparum
Description:
ChEMBL_983601
Residue:
230
Sequence:
MRFLIIHIAVIVLPFVLMIDVKRENSFFLRHSPKRLYKKADYNNMYDKIIKKQQNRIYDVSSQINQDNINGQNISFNLTFPNYDTSIDIEDIKKILPHRYPFLLVDKVIYMQPNKTIIGLKQVSTNEPFFNGHFPQKQIMPGVLQIEALAQLAGILCLKSDDSQKNNLFLFAGVDGVRWKKPVLPGDTLTMQANLISFKSSLGIAKLSGVGYVNGKVVINISEMTFALSK
  
Inhibitor
Name:
BDBM7457
Synonyms:
2-(3,4-dihydroxyphenyl)-3,7-dihydroxy-4H-chromen-4-one | 2-(3,4-dihydroxyphenyl)-3,7-dihydroxy-chromen-4-one | 2-(3,4-dihydroxyphenyl)-3,7-dihydroxy-chromone;dihydrate | CHEMBL31574 | Fisetin (14) | Fisetin, 15 | fisetin
Type:
Small organic molecule
Emp. Form.:
C15H10O6
Mol. Mass.:
286.2363
SMILES:
Oc1ccc2c(c1)oc(-c1ccc(O)c(O)c1)c(O)c2=O
Structure:
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