Reaction Details  Report a problem with these data
Target
Tyrosine-protein phosphatase non-receptor type 2
Ligand
BDBM50208362
Substrate
n/a
Meas. Tech.
ChEMBL_443212 (CHEMBL893460)
Ki
25000±n/a nM
Citation
 Shrestha, S; Bhattarai, BR; Chang, KJ; Lee, KH; Cho, H Methylenedisalicylic acid derivatives: new PTP1B inhibitors that confer resistance to diet-induced obesity. Bioorg Med Chem Lett 17:2760-4 (2007) [PubMed]  Article
Target
Name:
Tyrosine-protein phosphatase non-receptor type 2
Synonyms:
PTN2_HUMAN | PTPN2 | PTPT | T-cell protein tyrosine phosphatase (TCPTP) | T-cell protein-tyrosine phosphatase | TC-PTP | TCPTP | Tyrosine-protein phosphatase non-receptor type 2 | Tyrosine-protein phosphatase non-receptor type 2 (TC-PTP)
Type:
Protein
Mol. Mass.:
48481.80
Organism:
Homo sapiens (Human)
Description:
P17706
Residue:
415
Sequence:
MPTTIEREFEELDTQRRWQPLYLEIRNESHDYPHRVAKFPENRNRNRYRDVSPYDHSRVKLQNAENDYINASLVDIEEAQRSYILTQGPLPNTCCHFWLMVWQQKTKAVVMLNRIVEKESVKCAQYWPTDDQEMLFKETGFSVKLLSEDVKSYYTVHLLQLENINSGETRTISHFHYTTWPDFGVPESPASFLNFLFKVRESGSLNPDHGPAVIHCSAGIGRSGTFSLVDTCLVLMEKGDDINIKQVLLNMRKYRMGLIQTPDQLRFSYMAIIEGAKCIKGDSSIQKRWKELSKEDLSPAFDHSPNKIMTEKYNGNRIGLEEEKLTGDRCTGLSSKMQDTMEENSESALRKRIREDRKATTAQKVQQMKQRLNENERKRKRWLYWQPILTKMGFMSVILVGAFVGWTLFFQQNAL
  
Inhibitor
Name:
BDBM50208362
Synonyms:
3-benzyl-5-[(5-benzyl-3-carboxy-4-hydroxycyclohexa-1,3-dien-1-yl)methyl]-2-hydroxybenzoic acid | CHEMBL232049
Type:
Small organic molecule
Emp. Form.:
C29H26O6
Mol. Mass.:
470.5131
SMILES:
OC(=O)C1C=C(Cc2cc(Cc3ccccc3)c(O)c(c2)C(O)=O)CC(Cc2ccccc2)C1=O |t:4|
Structure:
Search PDB for entries with ligand similarity: