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Target
Carbonic anhydrase 3
Ligand
BDBM11611
Substrate
n/a
Meas. Tech.
ChEMBL_449604 (CHEMBL898699)
Ki
10700±n/a nM
Citation
 Nishimori, I; Minakuchi, T; Onishi, S; Vullo, D; Cecchi, A; Scozzafava, A; Supuran, CT Carbonic anhydrase inhibitors: cloning, characterization, and inhibition studies of the cytosolic isozyme III with sulfonamides. Bioorg Med Chem 15:7229-36 (2007) [PubMed]  Article
Target
Name:
Carbonic anhydrase 3
Synonyms:
CA-III | CA3 | CAH3_HUMAN | Carbonate dehydratase III | Carbonic Anhydrase III | Carbonic anhydrase | Carbonic anhydrase 3 (CA III) | Carbonic anhydrase III (CA III)
Type:
Enzyme
Mol. Mass.:
29562.11
Organism:
Homo sapiens (Human)
Description:
Human cloned isozyme.
Residue:
260
Sequence:
MAKEWGYASHNGPDHWHELFPNAKGENQSPVELHTKDIRHDPSLQPWSVSYDGGSAKTILNNGKTCRVVFDDTYDRSMLRGGPLPGPYRLRQFHLHWGSSDDHGSEHTVDGVKYAAELHLVHWNPKYNTFKEALKQRDGIAVIGIFLKIGHENGEFQIFLDALDKIKTKGKEAPFTKFDPSCLFPACRDYWTYQGSFTTPPCEECIVWLLLKEPMTVSSDQMAKLRSLLSSAENEPPVPLVSNWRPPQPINNRVVRASFK
  
Inhibitor
Name:
BDBM11611
Synonyms:
β-CA inhibitor, 10 | 4-Amino-3,5-dibromobenzenesulfonamide | 4-amino-3,5-dibromobenzene-1-sulfonamide | CHEMBL306195 | halogenosulfanilamide deriv. 12
Type:
Small organic molecule
Emp. Form.:
C6H6Br2N2O2S
Mol. Mass.:
329.997
SMILES:
Nc1c(Br)cc(cc1Br)S(N)(=O)=O
Structure:
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