Reaction Details  Report a problem with these data
Target
Sigma non-opioid intracellular receptor 1
Ligand
BDBM50225871
Substrate
n/a
Meas. Tech.
ChEMBL_451646 (CHEMBL901857)
Ki
6.5±n/a nM
Citation
 Geiger, C; Zelenka, C; Weigl, M; Fröhlich, R; Wibbeling, B; Lehmkuhl, K; Schepmann, D; Grünert, R; Bednarski, PJ; Wünsch, B Synthesis of bicyclic sigma receptor ligands with cytotoxic activity. J Med Chem 50:6144-53 (2007) [PubMed]  Article
Target
Name:
Sigma non-opioid intracellular receptor 1
Synonyms:
OPRS1 | SGMR1_CAVPO | SIGMAR1 | Sigma 1-type opioid receptor | Sigma non-opioid intracellular receptor 1 | Sigma-1 receptor | Sigma1-receptor | Sigma1R | Sterol isomerase-like protein
Type:
Protein
Mol. Mass.:
25307.17
Organism:
Cavia porcellus (Guinea pig)
Description:
Q60492
Residue:
223
Sequence:
MQWAVGRRWLWVALFLAAVAVLTQIVWLWLGTQNFVFQREEIAQLARQYAGLDHELAFSKLIVELRRLHPVHVLPDEELQWVFVNAGGWMGAMCLLHASLSEYVLLFGTALGSPRHSGRYWAEISDTIISGTFHQWREGTTKSEVFYPGETVVHGPGEATAVEWGPNTWMVEYGRGVIPSTLGFALADTVFSTQDFLTLFYTLRVYARALQLELTTYLFGQDP
  
Inhibitor
Name:
BDBM50225871
Synonyms:
(+)-(1R,2R,5S)-6-Benzyl-8-(4-methoxybenzyl)-6,8-diazabicyclo-[3.2.2]nonan-2-ol | (1R,2R,5S)-6-benzyl-8-(4-methoxybenzyl)-6,8-diazabicyclo[3.2.2]nonan-2-ol | CHEMBL238176
Type:
Small organic molecule
Emp. Form.:
C22H28N2O2
Mol. Mass.:
352.4699
SMILES:
COc1ccc(CN2C[C@@H]3CC[C@@H](O)[C@H]2CN3Cc2ccccc2)cc1 |r,TLB:6:7:16.15:10.11.12,13:12:16.15:8.7,THB:17:16:8.7:10.11.12|
Structure:
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