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Target
Isoprenyl transferase
Ligand
BDBM50372764
Substrate
n/a
Meas. Tech.
ChEMBL_465860 (CHEMBL951083)
IC50
19000±n/a nM
Citation
 Peukert, S; Sun, Y; Zhang, R; Hurley, B; Sabio, M; Shen, X; Gray, C; Dzink-Fox, J; Tao, J; Cebula, R; Wattanasin, S Design and structure-activity relationships of potent and selective inhibitors of undecaprenyl pyrophosphate synthase (UPPS): tetramic, tetronic acids and dihydropyridin-2-ones. Bioorg Med Chem Lett 18:1840-4 (2008) [PubMed]  Article
Target
Name:
Isoprenyl transferase
Synonyms:
Di-trans,poly-cis-decaprenylcistransferase | Ditrans,polycis-undecaprenyl-diphosphate synthase | ISPT_STRPN | UDS | UPP synthase | Undecaprenyl diphosphate synthase | Undecaprenyl pyrophosphate synthase | uppS
Type:
PROTEIN
Mol. Mass.:
28705.02
Organism:
Streptococcus pneumoniae
Description:
ChEMBL_465860
Residue:
252
Sequence:
MFGFFKKDKAVEVEVPTQVPAHIGIIMDGNGRWAKKRMQPRVFGHKAGMEALQTVTKAANKLGVKVITVYAFSTENWTRPDQEVKFIMNLPVEFYDNYVPELHANNVKIQMIGETDRLPKQTFEALTKAEELTKNNTGLILNFALNYGGRAEITQALKLISQDVLDAKINPGDITEELIGNYLFTQHLPKDLRDPDLIIRTSGELRLSNFLPWQGAYSELYFTDTLWPDFDEAALQEAILAYNRRHRRFGGV
  
Inhibitor
Name:
BDBM50372764
Synonyms:
CHEMBL272703
Type:
Small organic molecule
Emp. Form.:
C24H28N2O4
Mol. Mass.:
408.4901
SMILES:
CCCCCCOc1ccc(NC(=O)C2C(=O)NC(Cc3ccccc3)C2=O)cc1
Structure:
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