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Target
Mitogen-activated protein kinase 14
Ligand
BDBM50164228
Substrate
n/a
Meas. Tech.
ChEMBL_468804 (CHEMBL932044)
IC50
195±n/a nM
Citation
 Mader, M; de Dios, A; Shih, C; Bonjouklian, R; Li, T; White, W; López de Uralde, B; Sánchez-Martinez, C; del Prado, M; Jaramillo, C; de Diego, E; Martín Cabrejas, LM; Dominguez, C; Montero, C; Shepherd, T; Dally, R; Toth, JE; Chatterjee, A; Pleite, S; Blanco-Urgoiti, J; Perez, L; Barberis, M; Lorite, MJ; Jambrina, E; Nevill, CR; Lee, PA; Schultz, RC; Wolos, JA; Li, LC; Campbell, RM; Anderson, BD Imidazolyl benzimidazoles and imidazo[4,5-b]pyridines as potent p38alpha MAP kinase inhibitors with excellent in vivo antiinflammatory properties. Bioorg Med Chem Lett 18:179-83 (2008) [PubMed]  Article
Target
Name:
Mitogen-activated protein kinase 14
Synonyms:
Crk1 | Csbp1 | Csbp2 | MAP Kinase p38 alpha | MAP kinase p38 | MK14_MOUSE | Mapk14 | Mitogen-activated protein kinase 14 | Mitogen-activated protein kinase p38 alpha
Type:
Enzyme
Mol. Mass.:
41281.22
Organism:
Mus musculus (mouse)
Description:
The full-length open reading frame of murine p38 alpha was cloned and expressed in E. coli.. Soluble murine p38R was extracted from cell pellets and purified using ion-exchange chromatography.
Residue:
360
Sequence:
MSQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGHRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLAQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQYHDPDDEPVADPYDQSFESRDLLIDEWKSLTYDEVISFVPPPLDQEEMES
  
Inhibitor
Name:
BDBM50164228
Synonyms:
1-(isopropylsulfonyl)-6-(4-phenyl-1H-imidazol-5-yl)-1H-benzo[d]imidazol-2-amine | 6-(5-Phenyl-3H-imidazol-4-yl)-1-(propane-2-sulfonyl)-1H-benzoimidazol-2-ylamine | CHEMBL192848
Type:
Small organic molecule
Emp. Form.:
C19H19N5O2S
Mol. Mass.:
381.451
SMILES:
CC(C)S(=O)(=O)n1c(N)nc2ccc(cc12)-c1[nH]cnc1-c1ccccc1
Structure:
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