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Target
Histone deacetylase 1
Ligand
BDBM50375538
Substrate
n/a
Meas. Tech.
ChEMBL_472925 (CHEMBL921168)
IC50
2610±n/a nM
Citation
 Schäfer, S; Saunders, L; Eliseeva, E; Velena, A; Jung, M; Schwienhorst, A; Strasser, A; Dickmanns, A; Ficner, R; Schlimme, S; Sippl, W; Verdin, E; Jung, M Phenylalanine-containing hydroxamic acids as selective inhibitors of class IIb histone deacetylases (HDACs). Bioorg Med Chem 16:2011-33 (2008) [PubMed]  Article
Target
Name:
Histone deacetylase 1
Synonyms:
Cereblon/Histone deacetylase 1 | HD1 | HDAC1 | HDAC1_HUMAN | Histone deacetylase 1 (HDAC1) | Human HDAC1 | RPD3L1
Type:
Enzyme
Mol. Mass.:
55090.27
Organism:
Homo sapiens (Human)
Description:
Q13547
Residue:
482
Sequence:
MAQTQGTRRKVCYYYDGDVGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKANAEEMTKYHSDDYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVASAVKLNKQQTDIAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHHGDGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNYPLRDGIDDESYEAIFKPVMSKVMEMFQPSAVVLQCGSDSLSGDRLGCFNLTIKGHAKCVEFVKSFNLPMLMLGGGGYTIRNVARCWTYETAVALDTEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTNEYLEKIKQRLFENLRMLPHAPGVQMQAIPEDAIPEESGDEDEDDPDKRISICSSDKRIACEEEFSDSEEEGEGGRKNSSNFKKAKRVKTEDEKEKDPEEKKEVTEEEKTKEEKPEAKGVKEEVKLA
  
Inhibitor
Name:
BDBM50375538
Synonyms:
CHEMBL427776
Type:
Small organic molecule
Emp. Form.:
C22H28N2O6
Mol. Mass.:
416.4675
SMILES:
COC(=O)[C@H](Cc1ccc(cc1)-c1ccco1)NC(=O)CCCCCCC(=O)NO
Structure:
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