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Target
Mitogen-activated protein kinase 14
Ligand
BDBM50375802
Substrate
n/a
Meas. Tech.
ChEMBL_474267 (CHEMBL935072)
IC50
5±n/a nM
Citation
 Chen, MH; Fitzgerald, P; Singh, SB; O'Neill, EA; Schwartz, CD; Thompson, CM; O'Keefe, SJ; Zaller, DM; Doherty, JB Synthesis and biological activity of quinolinone and dihydroquinolinone p38 MAP kinase inhibitors. Bioorg Med Chem Lett 18:2222-6 (2008) [PubMed]  Article
Target
Name:
Mitogen-activated protein kinase 14
Synonyms:
CSAID-binding protein | CSBP | CSBP1 | CSBP2 | CSPB1 | Cytokine suppressive anti-inflammatory drug-binding protein | MAP kinase 14 | MAP kinase MXI2 | MAP kinase p38 alpha | MAPK 14 | MAPK14 | MAX-interacting protein 2 | MK14_HUMAN | MXI2 | Mitogen-activated protein kinase p38 alpha | SAPK2A | Stress-activated protein kinase 2a | p38 MAP kinase alpha/beta
Type:
Serine/threonine-protein kinase
Mol. Mass.:
41286.76
Organism:
Homo sapiens (Human)
Description:
Q16539
Residue:
360
Sequence:
MSQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQYHDPDDEPVADPYDQSFESRDLLIDEWKSLTYDEVISFVPPPLDQEEMES
  
Inhibitor
Name:
BDBM50375802
Synonyms:
CHEMBL271850
Type:
Small organic molecule
Emp. Form.:
C21H12Cl3NO3
Mol. Mass.:
432.684
SMILES:
Oc1cc(-c2ccccc2Cl)c2cc(O)c(=O)n(-c3c(Cl)cccc3Cl)c2c1 |(-.48,2.13,;-1.81,1.35,;-1.81,-.19,;-3.14,-.96,;-3.14,-2.5,;-4.48,-3.27,;-4.48,-4.81,;-3.14,-5.58,;-1.8,-4.8,;-1.81,-3.27,;-.47,-2.49,;-4.47,-.19,;-5.79,-.96,;-7.12,-.19,;-8.46,-.97,;-7.12,1.35,;-8.46,2.11,;-5.79,2.13,;-5.79,3.67,;-7.12,4.43,;-8.45,3.66,;-7.12,5.97,;-5.78,6.75,;-4.45,5.98,;-4.45,4.44,;-3.11,3.67,;-4.46,1.35,;-3.14,2.11,)|
Structure:
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