Reaction Details  Report a problem with these data
Target
Dual specificity protein phosphatase 3
Ligand
BDBM50335895
Substrate
n/a
Meas. Tech.
ChEMBL_479127 (CHEMBL925806)
IC50
103000±n/a nM
Citation
 Yu, X; Sun, JP; He, Y; Guo, X; Liu, S; Zhou, B; Hudmon, A; Zhang, ZY Structure, inhibitor, and regulatory mechanism of Lyp, a lymphoid-specific tyrosine phosphatase implicated in autoimmune diseases. Proc Natl Acad Sci U S A 104:19767-72 (2007) [PubMed]  Article
Target
Name:
Dual specificity protein phosphatase 3
Synonyms:
DUS3_HUMAN | DUSP3 | Dual specificity protein phosphatase (VHR) | Dual specificity protein phosphatase 3 | Dual specificity protein phosphatase VHR | Protein Tyrosine Phosphatase VHR | Tyrosine-protein phosphatase non-receptor type 1 | VHR
Type:
Hydrolase
Mol. Mass.:
20480.58
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
185
Sequence:
MSGSFELSVQDLNDLLSDGSGCYSLPSQPCNEVTPRIYVGNASVAQDIPKLQKLGITHVLNAAEGRSFMHVNTNANFYKDSGITYLGIKANDTQEFNLSAYFERAADFIDQALAQKNGRVLVHCREGYSRSPTLVIAYLMMRQKMDVKSALSIVRQNREIGPNDGFLAQLCQLNDRLAKEGKLKP
  
Inhibitor
Name:
BDBM50335895
Synonyms:
6-hydroxy-3-(1-(4-(naphthalen-1-ylamino)-4-oxobutyl)-1H-1,2,3-triazol-4-yl)-2-phenylbenzofuran-5-carboxylic acid | CHEMBL260920
Type:
Small organic molecule
Emp. Form.:
C31H24N4O5
Mol. Mass.:
532.5461
SMILES:
OC(=O)c1cc2c(-c3cn(CCCC(=O)Nc4cccc5ccccc45)nn3)c(oc2cc1O)-c1ccccc1
Structure:
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