Reaction Details  Report a problem with these data
Target
Muscarinic acetylcholine receptor M1
Ligand
BDBM50314273
Substrate
n/a
Meas. Tech.
ChEMBL_624293 (CHEMBL1106978)
Ki
>10000±n/a nM
Citation
 Moree, WJ; Jovic, F; Coon, T; Yu, J; Li, BF; Tucci, FC; Marinkovic, D; Gross, RS; Malany, S; Bradbury, MJ; Hernandez, LM; O'Brien, Z; Wen, J; Wang, H; Hoare, SR; Petroski, RE; Sacaan, A; Madan, A; Crowe, PD; Beaton, G Novel benzothiophene H1-antihistamines for the treatment of insomnia. Bioorg Med Chem Lett 20:2316-20 (2010) [PubMed]  Article
Target
Name:
Muscarinic acetylcholine receptor M1
Synonyms:
ACM1_HUMAN | CHRM1 | Cholinergic receptor, muscarinic 1 | Cholinergic, muscarinic M1
Type:
Protein
Mol. Mass.:
51442.54
Organism:
Homo sapiens (Human)
Description:
P11229
Residue:
460
Sequence:
MNTSAPPAVSPNITVLAPGKGPWQVAFIGITTGLLSLATVTGNLLVLISFKVNTELKTVNNYFLLSLACADLIIGTFSMNLYTTYLLMGHWALGTLACDLWLALDYVASNASVMNLLLISFDRYFSVTRPLSYRAKRTPRRAALMIGLAWLVSFVLWAPAILFWQYLVGERTVLAGQCYIQFLSQPIITFGTAMAAFYLPVTVMCTLYWRIYRETENRARELAALQGSETPGKGGGSSSSSERSQPGAEGSPETPPGRCCRCCRAPRLLQAYSWKEEEEEDEGSMESLTSSEGEEPGSEVVIKMPMVDPEAQAPTKQPPRSSPNTVKRPTKKGRDRAGKGQKPRGKEQLAKRKTFSLVKEKKAARTLSAILLAFILTWTPYNIMVLVSTFCKDCVPETLWELGYWLCYVNSTINPMCYALCNKAFRDTFRLLLLCRWDKRRWRKIPKRPGSVHRTPSRQC
  
Inhibitor
Name:
BDBM50314273
Synonyms:
(-)-(R)-N,N-dimethyl-2-(3-(1-(2-methylpyridin-3-yl)ethyl)benzo[b]thiophen-2-yl)ethanamine | CHEMBL1092813
Type:
Small organic molecule
Emp. Form.:
C20H24N2S
Mol. Mass.:
324.483
SMILES:
C[C@@H](c1c(CCN(C)C)sc2ccccc12)c1cccnc1C |r|
Structure:
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