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Target
Cytochrome P450 2D6
Ligand
BDBM50384612
Substrate
n/a
Meas. Tech.
ChEMBL_820773 (CHEMBL2038331)
IC50
>50000±n/a nM
Citation
 Palani, A; Rao, AU; Chen, X; Huang, X; Su, J; Tang, H; Huang, Y; Qin, J; Xiao, D; Degrado, S; Sofolarides, M; Zhu, X; Liu, Z; McKittrick, B; Zhou, W; Aslanian, R; Greenlee, WJ; Senior, M; Cheewatrakoolpong, B; Zhang, H; Farley, C; Cook, J; Kurowski, S; Li, Q; van Heek, M; Wang, G; Hsieh, Y; Li, F; Greenfeder, S; Chintala, M Discovery of SCH 900271, a Potent Nicotinic Acid Receptor Agonist for the Treatment of Dyslipidemia. ACS Med Chem Lett 3:63-68 (2012) [PubMed]  Article
Target
Name:
Cytochrome P450 2D6
Synonyms:
CP2D6_HUMAN | CYP2D6 | CYP2DL1 | CYPIID6 | Cytochrome P450 2D6 (CYP2D6) | Debrisoquine 4-hydroxylase | P450-DB1
Type:
Protein
Mol. Mass.:
55774.82
Organism:
Homo sapiens (Human)
Description:
P10635
Residue:
497
Sequence:
MGLEALVPLAVIVAIFLLLVDLMHRRQRWAARYPPGPLPLPGLGNLLHVDFQNTPYCFDQLRRRFGDVFSLQLAWTPVVVLNGLAAVREALVTHGEDTADRPPVPITQILGFGPRSQGVFLARYGPAWREQRRFSVSTLRNLGLGKKSLEQWVTEEAACLCAAFANHSGRPFRPNGLLDKAVSNVIASLTCGRRFEYDDPRFLRLLDLAQEGLKEESGFLREVLNAVPVLLHIPALAGKVLRFQKAFLTQLDELLTEHRMTWDPAQPPRDLTEAFLAEMEKAKGNPESSFNDENLRIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVIHEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHFLDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFSFSVPTGQPRPSHHGVFAFLVSPSPYELCAVPR
  
Inhibitor
Name:
BDBM50384612
Synonyms:
CHEMBL2036958
Type:
Small organic molecule
Emp. Form.:
C14H16N2O4
Mol. Mass.:
276.2878
SMILES:
CC1(CCCc2cc(=O)oc3[nH]c(=O)[nH]c(=O)c23)CC1
Structure:
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