Reaction Details  Report a problem with these data
Target
Peroxisome proliferator-activated receptor alpha
Ligand
BDBM50181907
Substrate
n/a
Meas. Tech.
ChEMBL_822292 (CHEMBL2038446)
IC50
414±n/a nM
Citation
 Méndez-Lucio, O; Pérez-Villanueva, J; Castillo, R; Medina-Franco, JL Activity landscape modeling of PPAR ligands with dual-activity difference maps. Bioorg Med Chem 20:3523-32 (2012) [PubMed]  Article
Target
Name:
Peroxisome proliferator-activated receptor alpha
Synonyms:
NR1C1 | Nuclear receptor subfamily 1 group C member 1 | PPAR | PPAR alpha/gamma | PPAR-alpha | PPARA | PPARA_HUMAN | Peroxisome Proliferator-Activated Receptor alpha | Peroxisome proliferator-activated receptor | Peroxisome proliferator-activated receptor alpha (PPAR alpha)
Type:
Enzyme
Mol. Mass.:
52222.08
Organism:
Homo sapiens (Human)
Description:
Q07869
Residue:
468
Sequence:
MVDTESPLCPLSPLEAGDLESPLSEEFLQEMGNIQEISQSIGEDSSGSFGFTEYQYLGSCPGSDGSVITDTLSPASSPSSVTYPVVPGSVDESPSGALNIECRICGDKASGYHYGVHACEGCKGFFRRTIRLKLVYDKCDRSCKIQKKNRNKCQYCRFHKCLSVGMSHNAIRFGRMPRSEKAKLKAEILTCEHDIEDSETADLKSLAKRIYEAYLKNFNMNKVKARVILSGKASNNPPFVIHDMETLCMAEKTLVAKLVANGIQNKEAEVRIFHCCQCTSVETVTELTEFAKAIPGFANLDLNDQVTLLKYGVYEAIFAMLSSVMNKDGMLVAYGNGFITREFLKSLRKPFCDIMEPKFDFAMKFNALELDDSDISLFVAAIICCGDRPGLLNVGHIEKMQEGIVHVLRLHLQSNHPDDIFLFPKLLQKMADLRQLVTEHAQLVQIIKKTESDAALHPLLQEIYRDMY
  
Inhibitor
Name:
BDBM50181907
Synonyms:
2-(4-(3-(4-(4-fluorobenzoyl)-2-propylphenoxy)propoxy)-1H-indol-1-yl)acetic acid | CHEMBL201653
Type:
Small organic molecule
Emp. Form.:
C29H28FNO5
Mol. Mass.:
489.5347
SMILES:
CCCc1cc(ccc1OCCCOc1cccc2n(CC(O)=O)ccc12)C(=O)c1ccc(F)cc1
Structure:
Search PDB for entries with ligand similarity: