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Target
Glycogen synthase kinase-3 beta
Ligand
BDBM50390495
Substrate
n/a
Meas. Tech.
ChEMBL_835303 (CHEMBL2072009)
IC50
30800±n/a nM
Citation
 Hua, Z; Huang, X; Bregman, H; Chakka, N; DiMauro, EF; Doherty, EM; Goldstein, J; Gunaydin, H; Huang, H; Mercede, S; Newcomb, J; Patel, VF; Turci, SM; Yan, J; Wilson, C; Martin, MW 2-Phenylamino-6-cyano-1H-benzimidazole-based isoform selective casein kinase 1 gamma (CK1¿) inhibitors. Bioorg Med Chem Lett 22:5392-5 (2012) [PubMed]  Article
Target
Name:
Glycogen synthase kinase-3 beta
Synonyms:
GSK-3 beta | GSK-3, beta | GSK3B | GSK3B_HUMAN | Glycogen synthase kinase 3 beta (GSK3B) | Glycogen synthase kinase 3-beta (GSK3B) | Glycogen synthase kinase-3 beta (GSK-3B) | Glycogen synthase kinase-3 beta (GSK3 Beta) | Glycogen synthase kinase-3 beta (GSK3B) | Glycogen synthase kinase-3B (GSK-3B) | Glycogen synthase kinase-3beta (GSK3B) | Serine/threonine-protein kinase GSK3B
Type:
Enzyme
Mol. Mass.:
46756.38
Organism:
Homo sapiens (Human)
Description:
P49841
Residue:
420
Sequence:
MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPTNATAASDANTGDRGQTNNAASASASNST
  
Inhibitor
Name:
BDBM50390495
Synonyms:
CHEMBL2071609
Type:
Small organic molecule
Emp. Form.:
C20H14N4
Mol. Mass.:
310.352
SMILES:
N#Cc1ccc2nc(Nc3ccc(cc3)-c3ccccc3)[nH]c2c1
Structure:
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