Reaction Details  Report a problem with these data
Target
Casein kinase I isoform gamma-2
Ligand
BDBM50390495
Substrate
n/a
Meas. Tech.
ChEMBL_835304 (CHEMBL2072010)
IC50
4890±n/a nM
Citation
 Hua, Z; Huang, X; Bregman, H; Chakka, N; DiMauro, EF; Doherty, EM; Goldstein, J; Gunaydin, H; Huang, H; Mercede, S; Newcomb, J; Patel, VF; Turci, SM; Yan, J; Wilson, C; Martin, MW 2-Phenylamino-6-cyano-1H-benzimidazole-based isoform selective casein kinase 1 gamma (CK1¿) inhibitors. Bioorg Med Chem Lett 22:5392-5 (2012) [PubMed]  Article
Target
Name:
Casein kinase I isoform gamma-2
Synonyms:
CK1G2 | CSNK1G2 | Casein kinase I | Casein kinase I gamma 2 | KC1G2_HUMAN
Type:
PROTEIN
Mol. Mass.:
47475.36
Organism:
Homo sapiens (Human)
Description:
ChEMBL_774313
Residue:
415
Sequence:
MDFDKKGGKGETEEGRRMSKAGGGRSSHGIRSSGTSSGVLMVGPNFRVGKKIGCGNFGELRLGKNLYTNEYVAIKLEPIKSRAPQLHLEYRFYKQLSATEGVPQVYYFGPCGKYNAMVLELLGPSLEDLFDLCDRTFTLKTVLMIAIQLITRMEYVHTKSLIYRDVKPENFLVGRPGTKRQHAIHIIDFGLAKEYIDPETKKHIPYREHKSLTGTARYMSINTHLGKEQSRRDDLEALGHMFMYFLRGSLPWQGLKADTLKERYQKIGDTKRATPIEVLCENFPEEMATYLRYVRRLDFFEKPDYDYLRKLFTDLFDRSGFVFDYEYDWAGKPLPTPIGTVHTDLPSQPQLRDKTQPHSKNQALNSTNGELNADDPTAGHSNAPITAPAEVEVADETKCCCFFKRRKRKSLQRHK
  
Inhibitor
Name:
BDBM50390495
Synonyms:
CHEMBL2071609
Type:
Small organic molecule
Emp. Form.:
C20H14N4
Mol. Mass.:
310.352
SMILES:
N#Cc1ccc2nc(Nc3ccc(cc3)-c3ccccc3)[nH]c2c1
Structure:
Search PDB for entries with ligand similarity: