Reaction Details  Report a problem with these data
Target
Prostaglandin E2 receptor EP2 subtype
Ligand
BDBM50159774
Substrate
n/a
Meas. Tech.
ChEMBL_857865 (CHEMBL2169498)
Ki
1729±n/a nM
Citation
 Tomasch, M; Schwed, JS; Kuczka, K; Meyer Dos Santos, S; Harder, S; Nüsing, RM; Paulke, A; Stark, H Fluorescent Human EP3 Receptor Antagonists. ACS Med Chem Lett 3:774-779 (2012) [PubMed]  Article
Target
Name:
Prostaglandin E2 receptor EP2 subtype
Synonyms:
PE2R2_HUMAN | PGE receptor EP2 subtype | PTGER2 | Prostaglandin E2 | Prostaglandin E2 receptor | Prostaglandin E2 receptor EP4 subtype | Prostanoid EP2 Receptor
Type:
Enzyme
Mol. Mass.:
39775.71
Organism:
Homo sapiens (Human)
Description:
P43116
Residue:
358
Sequence:
MGNASNDSQSEDCETRQWLPPGESPAISSVMFSAGVLGNLIALALLARRWRGDVGCSAGRRSSLSLFHVLVTELVFTDLLGTCLISPVVLASYARNQTLVALAPESRACTYFAFAMTFFSLATMLMLFAMALERYLSIGHPYFYQRRVSRSGGLAVLPVIYAVSLLFCSLPLLDYGQYVQYCPGTWCFIRHGRTAYLQLYATLLLLLIVSVLACNFSVILNLIRMHRRSRRSRCGPSLGSGRGGPGARRRGERVSMAEETDHLILLAIMTITFAVCSLPFTIFAYMNETSSRKEKWDLQALRFLSINSIIDPWVFAILRPPVLRLMRSVLCCRISLRTQDATQTSCSTQSDASKQADL
  
Inhibitor
Name:
BDBM50159774
Synonyms:
(E)-3-{2-[(E)-3-(4-Benzyloxy-3-methoxy-phenyl)-propenyl]-phenyl}-acrylic acid; compound with (E)-3-{2-[(E)-3-(4-benzyloxy-3-methoxy-phenyl)-allyl]-phenyl}-acrylic acid | 3-(2-((E)-3-(4-(benzyloxy)-3-methoxyphenyl)prop-1-enyl)phenyl)acrylic acid | CHEMBL1237317 | CHEMBL180191
Type:
Small organic molecule
Emp. Form.:
C26H24O4
Mol. Mass.:
400.4664
SMILES:
COc1cc(C\C=C\c2ccccc2\C=C\C(O)=O)ccc1OCc1ccccc1
Structure:
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