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Target
Glycylpeptide N-tetradecanoyltransferase
Ligand
BDBM50397538
Substrate
n/a
Meas. Tech.
ChEMBL_862035 (CHEMBL2174064)
IC50
13000±n/a nM
Citation
 Yu, Z; Brannigan, JA; Moss, DK; Brzozowski, AM; Wilkinson, AJ; Holder, AA; Tate, EW; Leatherbarrow, RJ Design and synthesis of inhibitors of Plasmodium falciparum N-myristoyltransferase, a promising target for antimalarial drug discovery. J Med Chem 55:8879-90 (2012) [PubMed]  Article
Target
Name:
Glycylpeptide N-tetradecanoyltransferase
Synonyms:
Myristoyl-CoA:protein N-myristoyltransferase | NMT | NMT_PLAF7 | Peptide N-myristoyltransferase
Type:
PROTEIN
Mol. Mass.:
47977.09
Organism:
Plasmodium falciparum (isolate 3D7)
Description:
ChEMBL_862035
Residue:
410
Sequence:
MNDDKKDFVGRDLYQLIRNAKDKIKIDYKFWYTQPVPKINDEFDENVNEPFISDNKVEDVRKEEYKLPSGYAWCVCDITKENDRSDIYNLLTDNYVEDDDNVFRFNYSSEFLLWALSSPNYVKNWHIGVKYESTNKLVGFISAIPIDMCVNKNIIKMAEVNFLCVHKSLRSKRLAPVLIKEITRRINLESIWQAIYTAGVYLPKPISTARYFHRSINVKKLIEIGFSCLNTRLTMSRAIKLYRIDDTLNIKNLRLMKKKDIDGLQKLLNEHLKQYNLHAIFSKEDVAHWFTPIDQVIYTYVNEENGEIKDLISFYSLPSKVLGNNKYNILNAAFSFYNITTTTTFKNLIQDAICLAKRNNFDVFNALEVMDNYSVFQDLKFGEGDGSLKYYLYNWKCASCHPSKIGIVLL
  
Inhibitor
Name:
BDBM50397538
Synonyms:
CHEMBL2171231
Type:
Small organic molecule
Emp. Form.:
C22H24N2O3
Mol. Mass.:
364.4376
SMILES:
Cc1c(oc2cccc(OC3CCNCC3)c12)C(=O)NCc1ccccc1
Structure:
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