Reaction Details  Report a problem with these data
Target
Histidine-rich protein PFHRP-II
Ligand
BDBM50412261
Substrate
n/a
Meas. Tech.
ChEMBL_489429 (CHEMBL994375)
IC50
2900±n/a nM
Citation
 Huy, NT; Mizunuma, K; Kaur, K; Nhien, NT; Jain, M; Uyen, DT; Harada, S; Jain, R; Kamei, K 2-tert-butyl-8-quinolinamines exhibit potent blood schizontocidal antimalarial activity via inhibition of heme crystallization. Antimicrob Agents Chemother 51:2842-7 (2007) [PubMed]  Article
Target
Name:
Histidine-rich protein PFHRP-II
Synonyms:
HRP1_PLAFA | Histidine-rich protein | Histidine-rich protein PFHRP-II
Type:
PROTEIN
Mol. Mass.:
35156.49
Organism:
Plasmodium falciparum
Description:
ChEMBL_500704
Residue:
332
Sequence:
MVSFSKNKVLSAAVFASVLLLDNNNSAFNNNLCSKNAKGLNLNKRLLHETQAHVDDAHHAHHVADAHHAHHAHHAADAHHAHHAADAHHAHHAADAHHAHHAADAHHAHHAADAHHAHHAADAHHAHHAADAHHAHHAADAHHAHHAADAHHAHHAAYAHHAHHASDAHHAADAHHAAYAHHAHHAADAHHAADAHHAAYAHHAHHAADAHHAADAHHATDAHHAHHAADAHHATDAHHAADAHHAADAHHATDAHHAADAHHATDAHHAADAHHAADAHHATDSHHAHHAADAHHAAAHHATDAHHAAAHHATDAHHAAAHHEAATHCLRH
  
Inhibitor
Name:
BDBM50412261
Synonyms:
CHEMBL330383
Type:
Small organic molecule
Emp. Form.:
C19H29N3O
Mol. Mass.:
315.4531
SMILES:
COc1cc(NC(C)CCCN)c2nc(ccc2c1)C(C)(C)C
Structure:
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