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Target
D(2) dopamine receptor
Ligand
BDBM50414440
Substrate
n/a
Meas. Tech.
ChEMBL_577523 (CHEMBL1057875)
Ki
158.49±n/a nM
Citation
 Micheli, F; Holmes, I; Arista, L; Bonanomi, G; Braggio, S; Cardullo, F; Di Fabio, R; Donati, D; Gentile, G; Hamprecht, D; Terreni, S; Heidbreder, C; Savoia, C; Griffante, C; Worby, A Dopamine D(3) receptor antagonists: The quest for a potentially selective PET ligand. Part two: Lead optimization. Bioorg Med Chem Lett 19:4011-3 (2009) [PubMed]  Article
Target
Name:
D(2) dopamine receptor
Synonyms:
D(2) dopamine receptor | DOPAMINE D2 | DOPAMINE D2 Long | DOPAMINE D2 Short | DRD2 | DRD2_HUMAN | Dopamine D2 receptor | Dopamine D2 receptor (D2) | Dopamine D2 receptor (D2R) | Dopamine D2A | Dopamine2-like | d2
Type:
Cell-surface receptors
Mol. Mass.:
50647.10
Organism:
Homo sapiens (Human)
Description:
P14416
Residue:
443
Sequence:
MDPLNLSWYDDDLERQNWSRPFNGSDGKADRPHYNYYATLLTLLIAVIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMISIVWVLSFTISCPLLFGLNNADQNECIIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRRRRKRVNTKRSSRAFRAHLRAPLKGNCTHPEDMKLCTVIMKSNGSFPVNRRRVEAARRAQELEMEMLSSTSPPERTRYSPIPPSHHQLTLPDPSHHGLHSTPDSPAKPEKNGHAKDHPKIAKIFEIQTMPNGKTRTSLKTMSRRKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCDCNIPPVLYSAFTWLGYVNSAVNPIIYTTFNIEFRKAFLKILHC
  
Inhibitor
Name:
BDBM50414440
Synonyms:
CHEMBL559920
Type:
Small organic molecule
Emp. Form.:
C18H24F3N3O2
Mol. Mass.:
371.3973
SMILES:
COc1cccc(c1)N1CCN(CCN2CCC(CC2)C(F)(F)F)C1=O
Structure:
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