Reaction Details  Report a problem with these data
Target
D(2) dopamine receptor
Ligand
BDBM50414568
Substrate
n/a
Meas. Tech.
ChEMBL_582204 (CHEMBL1059864)
Ki
630.96±n/a nM
Citation
 Holmes, IP; Micheli, F; Gaines, S; Lorthioir, O; Watson, SP; Fabio, RD; Gentile, G; Heidbreder, C; Savoia, C; Worby, A Dopamine D3 receptor antagonists: the quest for a potentially selective PET ligand. Part one: lead identification. Bioorg Med Chem Lett 19:4799-801 (2009) [PubMed]  Article
Target
Name:
D(2) dopamine receptor
Synonyms:
D(2) dopamine receptor | DOPAMINE D2 | DOPAMINE D2 Long | DOPAMINE D2 Short | DRD2 | DRD2_HUMAN | Dopamine D2 receptor | Dopamine D2 receptor (D2) | Dopamine D2 receptor (D2R) | Dopamine D2A | Dopamine2-like | d2
Type:
Cell-surface receptors
Mol. Mass.:
50647.10
Organism:
Homo sapiens (Human)
Description:
P14416
Residue:
443
Sequence:
MDPLNLSWYDDDLERQNWSRPFNGSDGKADRPHYNYYATLLTLLIAVIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMISIVWVLSFTISCPLLFGLNNADQNECIIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRRRRKRVNTKRSSRAFRAHLRAPLKGNCTHPEDMKLCTVIMKSNGSFPVNRRRVEAARRAQELEMEMLSSTSPPERTRYSPIPPSHHQLTLPDPSHHGLHSTPDSPAKPEKNGHAKDHPKIAKIFEIQTMPNGKTRTSLKTMSRRKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCDCNIPPVLYSAFTWLGYVNSAVNPIIYTTFNIEFRKAFLKILHC
  
Inhibitor
Name:
BDBM50414568
Synonyms:
CHEMBL562836
Type:
Small organic molecule
Emp. Form.:
C22H32FN3O
Mol. Mass.:
373.5074
SMILES:
CN(CCN1CCN(C1=O)c1ccc(F)cc1)C[C@@]12CC[C@@H](CC1)C2(C)C |r|
Structure:
Search PDB for entries with ligand similarity: