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Target
Beta-1 adrenergic receptor
Ligand
BDBM50423297
Substrate
n/a
Meas. Tech.
ChEMBL_456088 (CHEMBL888097)
Kd
224±n/a nM
Citation
 Troxler, T; Hoyer, D; Langenegger, D; Neumann, P; Pfäffli, P; Schoeffter, P; Sorg, D; Swoboda, R; Hurth, K Identification and SAR of potent and selective non-peptide obeline somatostatin sst1 receptor antagonists. Bioorg Med Chem Lett 17:3983-7 (2007) [PubMed]  Article
Target
Name:
Beta-1 adrenergic receptor
Synonyms:
ADRB1 | ADRB1R | ADRB1_HUMAN | B1AR | Beta-1 adrenoceptor | Beta-1 adrenoreceptor | adrenergic Beta1
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
51338.40
Organism:
Homo sapiens (Human)
Description:
P08588
Residue:
477
Sequence:
MGAGVLVLGASEPGNLSSAAPLPDGAATAARLLVPASPPASLLPPASESPEPLSQQWTAGMGLLMALIVLLIVAGNVLVIVAIAKTPRLQTLTNLFIMSLASADLVMGLLVVPFGATIVVWGRWEYGSFFCELWTSVDVLCVTASIETLCVIALDRYLAITSPFRYQSLLTRARARGLVCTVWAISALVSFLPILMHWWRAESDEARRCYNDPKCCDFVTNRAYAIASSVVSFYVPLCIMAFVYLRVFREAQKQVKKIDSCERRFLGGPARPPSPSPSPVPAPAPPPGPPRPAAAAATAPLANGRAGKRRPSRLVALREQKALKTLGIIMGVFTLCWLPFFLANVVKAFHRELVPDRLFVFFNWLGYANSAFNPIIYCRSPDFRKAFQGLLCCARRAARRRHATHGDRPRASGCLARPGPPPSPGAASDDDDDDVVGATPPARLLEPWAGCNGGAAADSDSSLDEPCRPGFASESKV
  
Inhibitor
Name:
BDBM50423297
Synonyms:
CHEMBL251541 | Obelin
Type:
Small organic molecule
Emp. Form.:
C26H32N4O4
Mol. Mass.:
464.5567
SMILES:
COc1cccc2C[C@@H]3[C@H](C[C@H](CN3C)C(=O)N3CCN(CC3)c3ccc(cc3)[N+]([O-])=O)Cc12
Structure:
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