Reaction Details  Report a problem with these data
Target
Free fatty acid receptor 1
Ligand
BDBM50275597
Substrate
n/a
Meas. Tech.
ChEMBL_937510 (CHEMBL2320496)
EC50
46±n/a nM
Citation
 Christiansen, E; Due-Hansen, ME; Urban, C; Grundmann, M; Schmidt, J; Hansen, SV; Hudson, BD; Zaibi, M; Markussen, SB; Hagesaether, E; Milligan, G; Cawthorne, MA; Kostenis, E; Kassack, MU; Ulven, T Discovery of a potent and selective free fatty acid receptor 1 agonist with low lipophilicity and high oral bioavailability. J Med Chem 56:982-92 (2013) [PubMed]  Article
Target
Name:
Free fatty acid receptor 1
Synonyms:
FFAR1 | FFAR1_HUMAN | G-protein Coupled Receptor 40 | GPR40
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
31473.32
Organism:
Homo sapiens (Human)
Description:
O14842
Residue:
300
Sequence:
MDLPPQLSFGLYVAAFALGFPLNVLAIRGATAHARLRLTPSLVYALNLGCSDLLLTVSLPLKAVEALASGAWPLPASLCPVFAVAHFFPLYAGGGFLAALSAGRYLGAAFPLGYQAFRRPCYSWGVCAAIWALVLCHLGLVFGLEAPGGWLDHSNTSLGINTPVNGSPVCLEAWDPASAGPARFSLSLLLFFLPLAITAFCYVGCLRALARSGLTHRRKLRAAWVAGGALLTLLLCVGPYNASNVASFLYPNLGGSWRKLGLITGAWSVVLNPLVTGYLGRGPGLKTVCAARTQGGKSQK
  
Inhibitor
Name:
BDBM50275597
Synonyms:
3-(4-(o-Tolylethynyl)phenyl)propanoic acid | CHEMBL449588
Type:
Small organic molecule
Emp. Form.:
C18H16O2
Mol. Mass.:
264.3184
SMILES:
Cc1ccccc1C#Cc1ccc(CCC(O)=O)cc1
Structure:
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