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Target
Cyclin-dependent kinase 4
Ligand
BDBM50426474
Substrate
n/a
Meas. Tech.
ChEMBL_940532 (CHEMBL2327150)
IC50
>10000±n/a nM
Citation
 Liu, JJ; Higgins, B; Ju, G; Kolinsky, K; Luk, KC; Packman, K; Pizzolato, G; Ren, Y; Thakkar, K; Tovar, C; Zhang, Z; Wovkulich, PM Discovery of a highly potent, orally active mitosis/angiogenesis inhibitor r1530 for the treatment of solid tumors. ACS Med Chem Lett 4:259-63 (2013) [PubMed]  Article
Target
Name:
Cyclin-dependent kinase 4
Synonyms:
CDK4 | CDK4_HUMAN | Cell division protein kinase 4 | Cyclin-dependent kinase 4 (CDK 4) | PSK-J3
Type:
Enzyme Subunit
Mol. Mass.:
33731.96
Organism:
Homo sapiens (Human)
Description:
P11802
Residue:
303
Sequence:
MATSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVVTLWYRAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLHKDEGNPE
  
Inhibitor
Name:
BDBM50426474
Synonyms:
CHEMBL1980391
Type:
Small organic molecule
Emp. Form.:
C18H14ClFN4O
Mol. Mass.:
356.781
SMILES:
COc1cc2Nc3[nH]nc(C)c3N=C(c3ccccc3Cl)c2cc1F |t:13|
Structure:
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